Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001348 | 0.87 | KDM4E (0.67) | KMT2AHSD17B10KDM4EMEN1GFER | |
| SCHEMBL14191236 | 0.82 | PRKCI (0.46) | KMT2AHSD17B10KDM4EMEN1GFER | |
| SCHEMBL405878 | 0.81 | HDAC1 (0.65) | KMT2AHSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL27704672 | 0.81 | ALDH1A1 (0.53) | KMT2AHSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL2306741 | 0.80 | KMT2A (0.69) | KMT2AMEN1ALDH1A1HPGDRAB9A | |
| SCHEMBL18131322 | 0.80 | TDP1 (0.52) | KMT2AHSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL14884639 | 0.80 | MEN1 (0.68) | KMT2AKDM4EMEN1GFERALDH1A1 | |
| SCHEMBL15014104 | 0.79 | RAB9A (0.49) | HSD17B10KDM4EALDH1A1ALOX15POLB | |
| SCHEMBL9469411 | 0.79 | KDM4E (0.77) | HSD17B10KDM4EALDH1A1ALOX15POLB | |
| SCHEMBL796957 | 0.79 | ALDH1A1 (0.73) | KMT2AHSD17B10KDM4EMEN1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410155-B2 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-02 | — | — | US | disclosed |