Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12507027 | 0.85 | KLKB1 (0.39) | ALDH1A1LMNAPOLBMAPTKCNH2 | |
| SCHEMBL14823402 | 0.85 | TSHR (0.50) | TSHRHSD17B10MAPK1KMT2AALDH1A1 | |
| SCHEMBL21503615 | 0.81 | GABRA1 (0.37) | ALDH1A1LMNAPOLBMAPTKCNH2 | |
| SCHEMBL21054803 | 0.74 | HSD17B10 (0.55) | TSHRHSD17B10MAPK1KMT2AALDH1A1 | |
| SCHEMBL12506298 | 0.73 | CYP19A1 (0.40) | — | |
| Trifluoroacetic Acid SCHEMBL21492529 | 0.72 | KLKB1 (0.39) | ALDH1A1POLBKCNH2KLKB1 | |
| SCHEMBL12507024 | 0.72 | CYP19A1 (0.46) | KLKB1 | |
| Trifluoroacetic Acid SCHEMBL28529732 | 0.72 | TAS2R8 (0.41) | MAPK1ALDH1A1HTTRAB9ALMNA | |
| SCHEMBL753052 | 0.71 | HSD17B10 (0.64) | TSHRHSD17B10MAPK1KMT2AALDH1A1 | |
| SCHEMBL12414660 | 0.69 | KLKB1 (0.40) | ALDH1A1PKMMAPTKCNH2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410091-B1 | Process for preparation of substituted 2-amino-5-(5-(heterocyclemethyl)pyridin-2-yloxy)benzoic acid | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-04-02 | — | — | US | disclosed |