Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CRHBP | P24387 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | CRHR2 | Q13324 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | FNTA | P49354 | 2/20 | 0.61 |
| ▸ | FNTB | P49356 | 2/20 | 0.61 |
| ▸ | KLK7 | P49862 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10951751 | 0.96 | LMNA (1.00) | LMNAMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL10946494 | 0.89 | MEN1 (0.80) | LMNAMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL10954626 | 0.89 | LMNA (0.86) | LMNAMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL14826375 | 0.85 | LMNA (0.73) | LMNAMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL10948604 | 0.84 | LMNA (0.78) | LMNAMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL10952823 | 0.83 | LMNA (0.76) | LMNAMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL10954049 | 0.83 | LMNA (0.76) | LMNAMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL10953096 | 0.83 | LMNA (0.76) | LMNAMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL10956644 | 0.82 | GAA (0.74) | LMNAMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL10954297 | 0.82 | LMNA (0.74) | LMNAMEN1HTTKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10561666-B2 | Amido compounds as RORγt modulators and uses thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-02-18 | — | — | US | disclosed |
| US-20170065606-A1 | AMIDO COMPOUNDS AS RORyt MODULATORS AND USES THEREOF | NEW YORK UNIVERSITY | 2017-03-09 | — | — | US | disclosed |
| US-20170065606-A1 | AMIDO COMPOUNDS AS RORyt MODULATORS AND USES THEREOF | NEW YORK UNIVERSITY | 2017-03-09 | — | — | US | disclosed |
| US-9492439-B2 | Amido compounds as RORγt modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-9492439-B2 | Amido compounds as RORγt modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| EP-3002008-A1 | AMIDO COMPOUNDS AS RORYT MODULATORS AND USES THEREOF | New York University (US) | 2016-04-06 | — | — | EP | disclosed |
| US-20130085162-A1 | AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-04-04 | — | — | US | disclosed |
| US-20130085162-A1 | AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10561666-B2 | Amido compounds as RORγt modulators and uses thereof | RORB, RORA, RORC | LMNA 4213/4885MEN1 872/4885HTT 3267/4885 |
| US-20170065606-A1 | AMIDO COMPOUNDS AS RORyt MODULATORS AND USES THEREOF | RORB, RORA, RORC | LMNA 3482/4885MEN1 858/4885HTT 3917/4885 |
| US-20130085162-A1 | AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | RORB, RORA, RORC | LMNA 3482/4885MEN1 858/4885HTT 3917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.