Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21591743 | 0.88 | SIGMAR1 (0.48) | SIGMAR1MEN1POLBGAAMAPT | |
| SCHEMBL21457821 | 0.86 | NAMPT (0.53) | SIGMAR1MEN1GAAMAPTKMT2A | |
| SCHEMBL5677044 | 0.79 | MCHR1 (0.48) | SIGMAR1NAMPTAKT1NQO2 | |
| SCHEMBL20303810 | 0.77 | SIGMAR1 (0.56) | SIGMAR1MAPTNAMPTDRD2 | |
| SCHEMBL19211125 | 0.77 | SIGMAR1 (0.52) | SIGMAR1MEN1GAAMAPTKMT2A | |
| SCHEMBL14367982 | 0.77 | PRMT6 (0.56) | MEN1POLBGAAMAPTKMT2A | |
| SCHEMBL24641798 | 0.77 | GPR119 (0.50) | MEN1POLBGAAMAPTKMT2A | |
| SCHEMBL30017169 | 0.77 | GPR119 (0.50) | MEN1POLBGAAMAPTKMT2A | |
| SCHEMBL1718277 | 0.76 | NQO2 (0.51) | SIGMAR1POLBNAMPTAKT1NQO2 | |
| SCHEMBL5683294 | 0.76 | GPR119 (0.55) | MEN1MAPTKMT2ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760840-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013048942-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |