Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.48 |
| ▸ | UBE2M | P61081 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815095 | 1.00 | CCR2 (0.48) | CCR2UBE2MDCUN1D1DRD2ADRA1D | |
| SCHEMBL14833227 | 0.94 | DRD2 (0.45) | DRD2ADRA1DADRA1AADRA1BHTR6 | |
| SCHEMBL14815157 | 0.94 | DRD2 (0.45) | DRD2ADRA1DADRA1AADRA1BHTR6 | |
| SCHEMBL14833401 | 0.90 | UBE2M (0.46) | CCR2UBE2MDCUN1D1DRD2ADRA1D | |
| SCHEMBL14815089 | 0.90 | UBE2M (0.46) | CCR2UBE2MDCUN1D1DRD2ADRA1D | |
| SCHEMBL14833228 | 0.87 | DRD2 (0.42) | CCR2DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL14815110 | 0.87 | DRD2 (0.42) | CCR2DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL14815077 | 0.82 | DRD2 (0.47) | DRD2ADRA1DADRA1AADRA1BHTR6 | |
| SCHEMBL14833215 | 0.82 | DRD2 (0.47) | DRD2ADRA1DADRA1AADRA1BHTR6 | |
| SCHEMBL14814590 | 0.79 | DRD2 (0.52) | DRD2ADRA1DADRA1AADRA1BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013049164-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | claimed |
| WO-2013049164-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | disclosed |