Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 7/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14814985 | 1.00 | HSD11B1 (0.45) | HSD11B1HDAC8PTGDR2SYKTAS2R14 | |
| SCHEMBL14814596 | 0.82 | CYP3A4 (0.45) | HSD11B1TAS2R14IDH1HCRTR1HCRTR2 | |
| SCHEMBL14833328 | 0.82 | CYP3A4 (0.45) | HSD11B1TAS2R14IDH1HCRTR1HCRTR2 | |
| SCHEMBL14814937 | 0.82 | HTR1A (0.43) | HSD11B1HDAC8SYKSLC6A7CCNC | |
| SCHEMBL14815283 | 0.79 | PHGDH (0.40) | HSD11B1SYKIDH1HCRTR1HCRTR2 | |
| SCHEMBL14814959 | 0.78 | ADRB1 (0.43) | HSD11B1HDAC8SYKIDH1IDH2 | |
| SCHEMBL14814958 | 0.77 | CCR6 (0.46) | HSD11B1HCRTR1HCRTR2 | |
| SCHEMBL14815130 | 0.76 | DRD2 (0.42) | HSD11B1HDAC8SYKIDH1IDH2 | |
| SCHEMBL14815290 | 0.72 | HCRTR1 (0.42) | HSD11B1HDAC8PTGDR2SYKTAS2R14 | |
| SCHEMBL30775331 | 0.70 | IDH1 (0.57) | HDAC8PTGDR2SYKIDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013049164-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | disclosed |