Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18284816 | 0.89 | SIGMAR1 (0.39) | SIGMAR1KMT2AHTR2AMEN1OPRD1 | |
| SCHEMBL4759637 | 0.87 | HTR2A (0.38) | SIGMAR1KMT2AHTR2AOPRD1HTR2C | |
| SCHEMBL8109695 | 0.83 | SIGMAR1 (0.39) | SIGMAR1KMT2AHTR2AMEN1ADRB2 | |
| SCHEMBL2404059 | 0.77 | SIGMAR1 (0.35) | SIGMAR1KMT2AHTR2AOPRD1OPRM1 | |
| SCHEMBL27373175 | 0.75 | SIGMAR1 (0.37) | SIGMAR1KMT2AHTR2AOPRD1HTR2C | |
| Hydrochloric Acid SCHEMBL6830554 | 0.74 | HTR2A (0.42) | SIGMAR1KMT2AHTR2AMEN1NPSR1 | |
| SCHEMBL5385853 | 0.73 | ALDH1A1 (0.42) | KMT2AMEN1ADRB2NPSR1HTR2B | |
| SCHEMBL15094673 | 0.72 | APP (0.39) | SIGMAR1HTR2AOPRD1HTR2CHTR2B | |
| SCHEMBL8499176 | 0.72 | SIGMAR1 (0.36) | SIGMAR1KMT2AHTR2AOPRD1HTR2C | |
| SCHEMBL15824967 | 0.72 | ALDH1A1 (0.38) | KMT2AMEN1ALDH1A1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760862-A1 | 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013045413-A1 | 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2013-04-04 | — | — | WO | disclosed |