Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815391 | 0.79 | EPHX2 (0.41) | CRHR1CRHR2HPGDTRPV4 | |
| SCHEMBL14837218 | 0.73 | CHRNA7 (0.40) | — | |
| SCHEMBL14837038 | 0.72 | CRHR1 (0.35) | CRHR1CCKBRPTGDRPTGDR2TRPV4 | |
| SCHEMBL14815788 | 0.69 | TRPV4 (0.47) | TRPV4 | |
| SCHEMBL14833809 | 0.69 | CCKBR (0.36) | CCKBRCACNA1BTRPV4 | |
| SCHEMBL14816231 | 0.68 | EPHX2 (0.44) | HPGDPTGDR2TRPV4 | |
| SCHEMBL14815882 | 0.68 | KMT2A (0.43) | PTGDRPTGDR2TRPV4 | |
| SCHEMBL14815877 | 0.65 | PTGDR (0.42) | PTGDRPTGDR2TRPV4 | |
| SCHEMBL14815755 | 0.64 | TRPV4 (0.45) | PTGDRPTGDR2TRPV4 | |
| SCHEMBL4184624 | 0.64 | HPGD (0.52) | CRHR1CRHR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013049174-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-A]PYRAZINE SULFONAMIDES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | disclosed |