SCHEMBL1483546

SCHEMBL1483546

CC(C)(C)OC(=O)n1cc(CBr)c2ccccc21

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.67
EPHX1 P07099 1/20 0.54
PDE10A Q9Y233 1/20 0.49
HTR6 P50406 1/20 0.49
ADAM17 P78536 1/20 0.46
ACHE P22303 1/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
PIM1 P11309 1/20 0.45
MARK3 P27448 1/20 0.45
MAP4K2 Q12851 1/20 0.45
CAMK2B Q13554 1/20 0.45
PIM3 Q86V86 1/20 0.45
PIM2 Q9P1W9 1/20 0.45
CHRM2 P08172 1/20 0.43
CHRM4 P08173 1/20 0.43
CHRM1 P11229 1/20 0.43
CHRM3 P20309 1/20 0.43
BRD4 O60885 1/20 0.43
CREBBP Q92793 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29504836 1.00 L3MBTL1 (0.67) L3MBTL1EPHX1PDE10AHTR6ADAM17
SCHEMBL30859622 0.89 L3MBTL1 (0.65) L3MBTL1EPHX1PDE10AHTR6ADAM17
SCHEMBL4892277 0.89 L3MBTL1 (0.65) L3MBTL1EPHX1PDE10AHTR6ADAM17
SCHEMBL10088115 0.89 L3MBTL1 (0.74) L3MBTL1EPHX1PDE10AHTR6ADAM17
SCHEMBL1520892 0.89 L3MBTL1 (0.70) L3MBTL1EPHX1PDE10AHTR6ADAM17
SCHEMBL5740514 0.86 L3MBTL1 (0.65) L3MBTL1EPHX1PDE10AHTR6ADAM17
SCHEMBL13109139 0.86 L3MBTL1 (0.65) L3MBTL1EPHX1PDE10AHTR6ADAM17
SCHEMBL23522089 0.86 L3MBTL1 (0.67) L3MBTL1EPHX1PDE10AHTR6ADAM17
SCHEMBL22153097 0.86 L3MBTL1 (0.67) L3MBTL1EPHX1PDE10AHTR6ADAM17
SCHEMBL25911437 0.86 L3MBTL1 (0.67) L3MBTL1EPHX1PDE10AHTR6ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107328-A1 AGONISTS OF PARATHYROID HORMONE 1 AND INCRETIN RECEPTORS SEPTERNA, INC. (US) 2026-05-21 WO disclosed
CN-115959962-B Visible light-promoted halogenated alkane hydrodehalogenation method 中国科学院兰州化学物理研究所 2025-05-23 CN disclosed
WO-2024258728-A2 EPIDITHIODIKETOPIPERAZINE ANALOGS AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-12-19 WO disclosed
US-20240409542-A1 NOVEL COMPOUNDS SITRYX THERAPEUTICS LIMITED (GB) 2024-12-12 US disclosed
CN-118139864-A New compounds 西特瑞治疗有限公司 2024-06-04 CN disclosed
US-11999716-B2 WDR5 inhibitors and modulators VANDERBILT UNIVERSITY (US) 2024-06-04 US disclosed
US-20230406830-A1 [6,6] FUSED BICYCLIC HDAC8 INHIBITORS Valo Health, LLC 2023-12-21 US disclosed
CN-115959962-A Visible light promoted halogenated alkane hydrodehalogenation method 中国科学院兰州化学物理研究所 2023-04-14 CN disclosed
US-20230012362-A1 WDR5 INHIBITORS AND MODULATORS VANDERBILT UNIVERSITY 2023-01-12 US disclosed
US-11414392-B2 [6,6] fused bicyclic HDAC8 inhibitors VALO HEALTH, INC. (US) 2022-08-16 US disclosed
US-5859007-A TREATMENT OF DIABETES, OBESITY GLAXO WELLCOME INC. (US) 1999-01-12 US disclosed
US-5801248-A Stereoselective syntheses OXFORD ASYMMETRY INTERNATIONAL PLC. (GB) 1998-09-01 US disclosed
US-5795887-A Method of inducing cholecystokinin agonist activity using 1,4- Benzodiazepine compounds GLAXO WELLCOME INC. (US) 1998-08-18 US disclosed
EP-0755384-A1 CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES GLAXO WELLCOME INC. (US) 1997-01-29 EP disclosed
EP-0755394-A1 A METHOD OF INDUCING CHOLECYSTOKININ AGONIST ACTIVITY USING 1,4-BENZODIAZEPINE COMPOUNDS GLAXO WELLCOME INC. (US) 1997-01-29 EP disclosed
US-5554753-A Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis INDIANA UNIVERSITY FOUNDATION (US) 1996-09-10 US disclosed
WO-1995028399-A1 A METHOD OF INDUCING CHOLECYSTOKININ AGONIST ACTIVITY USING 1,4-BENZODIAZEPINE COMPOUNDS GLAXO WELLCOME INC. (US) 1995-10-26 WO disclosed
WO-1995028391-A1 CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES GLAXO WELLCOME INC. (US) 1995-10-26 WO disclosed
WO-1995006029-A1 ENANTIOSELECTIVE SYNTHESIS OF ALPHA - ALKYLATED AMINO ACID DERIVATIVES BY PHASE - TRANSFER CATALYSIS INDIANA UNIVERSITY FOUNDATION (US) 1995-03-02 WO disclosed
US-5173496-A Antiinflammatory agents ICI PHARMA (FR) 1992-12-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230406830-A1 [6,6] FUSED BICYCLIC HDAC8 INHIBITORS HDAC8, HDAC3, HDAC2 L3MBTL1 782/4885EPHX1 3467/4885PDE10A 3800/4885
US-20230012362-A1 WDR5 INHIBITORS AND MODULATORS WDR5, WDR1, WDR77 L3MBTL1 1089/4885EPHX1 2547/4885PDE10A 4355/4885
US-11414392-B2 [6,6] fused bicyclic HDAC8 inhibitors HDAC8, HDAC3, HDAC2 L3MBTL1 782/4885EPHX1 3467/4885PDE10A 3800/4885
US-11999716-B2 WDR5 inhibitors and modulators WDR5, WDR1, WDR3 L3MBTL1 1118/4885EPHX1 2637/4885PDE10A 4283/4885
US-20240409542-A1 NOVEL COMPOUNDS CD47, GPR119, LRBA L3MBTL1 3300/4885EPHX1 714/4885PDE10A 2788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.