Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232064 | 0.83 | FAAH (0.44) | MEN1KMT2AATMLMNAALDH1A1 | |
| SCHEMBL3116168 | 0.82 | MEN1 (0.53) | MEN1KMT2AATMFAAHHRH3 | |
| SCHEMBL2024157 | 0.82 | KMT2A (0.53) | MEN1KMT2AATMLMNAALDH1A1 | |
| SCHEMBL1977079 | 0.82 | KMT2A (0.77) | MEN1KMT2AATMLMNAALDH1A1 | |
| SCHEMBL209098 | 0.82 | TRPV6 (0.55) | MEN1KMT2AATMTRPV6FAAH | |
| SCHEMBL30042412 | 0.80 | MEN1 (0.49) | MEN1KMT2AATMTRPV6KCNH2 | |
| SCHEMBL2933302 | 0.80 | MEN1 (0.49) | MEN1KMT2AATMTRPV6KCNH2 | |
| SCHEMBL3617972 | 0.80 | ALDH1A1 (0.68) | MEN1KMT2ALMNAALDH1A1HPGD | |
| SCHEMBL3869875 | 0.79 | HRH3 (0.55) | TRPV6KCNH2CACNA1IALDH1A1HRH3 | |
| SCHEMBL29725200 | 0.79 | HRH3 (0.55) | TRPV6KCNH2CACNA1IALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746072-A1 | 2H-INDAZOLE DERIVATIVES AS CDK4 AND CDK6 INHIBITORS AND THERAPEUTIC USES THEREOF | Beta Pharma, Inc. (US) | 2020-12-09 | — | — | EP | disclosed |
| US-10696678-B2 | Kinase inhibitor, and preparing method and pharmaceutical use thereof | GAN & LEE PHARMACEUTICALS (CN) | 2020-06-30 | — | — | US | disclosed |
| WO-2019148161-A1 | 2H-INDAZOLE DERIVATIVES AS CDK4 AND CDK6 INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA, INC. (US) | 2019-08-01 | — | — | WO | disclosed |
| US-20180305363-A1 | KINASE INHIBITOR, AND PREPARING METHOD AND PHARMACEUTICAL USE THEREOF | GAN&LEE PHARMACEUTICALS (CN) | 2018-10-25 | — | — | US | disclosed |
| EP-3369734-A1 | KINASE INHIBITOR, AND PREPARING METHOD AND PHARMACEUTICAL USE THEREOF | Gan & Lee Pharmaceuticals (CN) | 2018-09-05 | — | — | EP | disclosed |
| US-20130096136-A1 | Inhibitors of Protein Tyrosine Kinase Activity | METHYLGENE INC. (CA) | 2013-04-18 | — | — | US | disclosed |
| US-20130090327-A1 | Inhibitors of Protein Tyrosine Kinase Activity | METHYLGENE INC. (CA) | 2013-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10696678-B2 | Kinase inhibitor, and preparing method and pharmaceutical use thereof | CDK1, MAP3K1, CSNK1A1 | MEN1 427/4885KMT2A 1164/4885ATM 476/4885 |
| US-20130096136-A1 | Inhibitors of Protein Tyrosine Kinase Activity | KDR, FLT1, FLT4 | MEN1 2433/4885KMT2A 3825/4885ATM 1098/4885 |
| US-20180305363-A1 | KINASE INHIBITOR, AND PREPARING METHOD AND PHARMACEUTICAL USE THEREOF | CDK1, MAP3K1, CSNK1A1 | MEN1 427/4885KMT2A 1164/4885ATM 476/4885 |
| US-20130090327-A1 | Inhibitors of Protein Tyrosine Kinase Activity | KDR, FLT1, FLT4 | MEN1 2433/4885KMT2A 3825/4885ATM 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.