Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 16/20 | 0.78 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | PPARD | Q03181 | 1/20 | 0.63 |
| ▸ | PPARA | Q07869 | 1/20 | 0.63 |
| ▸ | IL6 | P05231 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14841399 | 0.93 | PPARG (0.68) | PPARGCYP2C8NR1I2PPARDPPARA | |
| SCHEMBL27188277 | 0.88 | PPARG (1.00) | PPARGCYP2C8NR1I2PPARDPPARA | |
| SCHEMBL9987169 | 0.84 | IL6 (0.65) | PPARGCYP2C8NR1I2PPARDPPARA | |
| SCHEMBL29113778 | 0.83 | KMT2A (0.74) | PPARGCYP2C8PPARAMAPT | |
| SCHEMBL7131095 | 0.82 | PPARG (0.70) | PPARGCYP2C8PPARAMAPT | |
| SCHEMBL14841318 | 0.81 | STAT3 (0.74) | PPARGCYP2C8IL6STAT3MAPT | |
| SCHEMBL27188331 | 0.80 | PPARG (1.00) | PPARGCYP2C8NR1I2PPARDPPARA | |
| SCHEMBL14841280 | 0.79 | IL6 (0.89) | PPARGIL6STAT3MAPT | |
| SCHEMBL14841737 | 0.78 | STAT3 (0.81) | IL6STAT3PTGS2MAPT | |
| SCHEMBL7130372 | 0.78 | PPARG (0.63) | PPARGCYP2C8PPARAPTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157280-A | Composition for preventing or treating chronic kidney disease comprising compound inducing expression of anti-aging gene klotho | 克洛索科学公司 | 2023-12-01 | — | — | CN | claimed |
| CN-117136055-A | Composition for preventing or treating degenerative neurological diseases comprising compound inducing expression of anti-aging gene klotho | 克洛索科学公司 | 2023-11-28 | — | — | CN | claimed |
| CN-114502541-A | Compound for inducing expression of anti-aging gene KLOTHO and application thereof | 克洛索科学公司 | 2022-05-13 | — | — | CN | claimed |
| US-8614240-B2 | Benzoxazole derivatives having inhibitory activity against interleukin-6, preparation method thereof, and pharmaceutical composition containing the same | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2013-12-24 | — | — | US | claimed |
| US-20130090480-A1 | Benzoxazole Derivatives Having Inhibitory Activity Against Interleukin-6, Preparation Method Thereof, and Pharmaceutical Composition Containing the Same | EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION (KR) | 2013-04-11 | — | — | US | claimed |
| US-20240216341-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | KLOTHO SCIENCES (KR) | 2024-07-04 | — | — | US | disclosed |
| US-20240216341-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | KLOTHO SCIENCES (KR) | 2024-07-04 | — | — | US | disclosed |
| CN-114502541-B | Compounds inducing expression of anti-aging gene KLOTHO and application thereof | 克洛索科学公司 | 2024-06-07 | — | — | CN | disclosed |
| EP-4317140-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | Klotho Sciences (KR) | 2024-02-07 | — | — | EP | disclosed |
| CN-117157280-A | Composition for preventing or treating chronic kidney disease comprising compound inducing expression of anti-aging gene klotho | 克洛索科学公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-117136055-A | Composition for preventing or treating degenerative neurological diseases comprising compound inducing expression of anti-aging gene klotho | 克洛索科学公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022211574-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | 주식회사 클로소사이언스 | 2022-10-06 | — | — | WO | disclosed |
| WO-2022211420-A1 | COMPOSITION FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASE COMPRISING COMPOUND INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO | 주식회사 클로소사이언스 | 2022-10-06 | — | — | WO | disclosed |
| EP-4039676-A1 | COMPOUND FOR INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO AND USE THEREOF | Klotho Sciences (KR) | 2022-08-10 | — | — | EP | disclosed |
| CN-114502541-A | Compound for inducing expression of anti-aging gene KLOTHO and application thereof | 克洛索科学公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021066608-A1 | COMPOUND FOR INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO AND USE THEREOF | 주식회사 클로소사이언스 | 2021-04-08 | — | — | WO | disclosed |
| US-8614240-B2 | Benzoxazole derivatives having inhibitory activity against interleukin-6, preparation method thereof, and pharmaceutical composition containing the same | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2013-12-24 | — | — | US | disclosed |
| US-20130090480-A1 | Benzoxazole Derivatives Having Inhibitory Activity Against Interleukin-6, Preparation Method Thereof, and Pharmaceutical Composition Containing the Same | EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION (KR) | 2013-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240216341-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | GLA, CTSA, FGF23 | PPARG 192/4885CYP2C8 4596/4885NR1I2 1349/4885 |
| US-20130090480-A1 | Benzoxazole Derivatives Having Inhibitory Activity Against Interleukin-6, Preparation Method Thereof, and Pharmaceutical Composition Containing the Same | IL6, IL1B, IL1A | PPARG 298/4885CYP2C8 141/4885NR1I2 530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.