Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 9/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.65 |
| ▸ | POLB | P06746 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3999404 | 0.82 | ALDH1A1 (0.76) | ALDH1A1MEN1KMT2APOLBMAPT | |
| SCHEMBL2836012 | 0.82 | POLB (0.63) | ALDH1A1MEN1KMT2APOLBMAPT | |
| SCHEMBL31239064 | 0.80 | NPC1 (0.69) | ALDH1A1MEN1KMT2APOLBMAPT | |
| SCHEMBL432126 | 0.80 | CYP19A1 (0.67) | ALDH1A1MEN1KMT2APOLBMAPT | |
| SCHEMBL3740206 | 0.79 | NPC1 (0.63) | ALDH1A1MEN1KMT2AL3MBTL1ADAMTS5 | |
| SCHEMBL7778609 | 0.79 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2APOLBMAPT | |
| SCHEMBL3726972 | 0.79 | UBE2N (0.59) | ALDH1A1MEN1KMT2APOLBMAPT | |
| SCHEMBL8626932 | 0.78 | POLB (0.59) | ALDH1A1MEN1KMT2APOLBMAPT | |
| SCHEMBL17988265 | 0.78 | KMT2A (0.68) | ALDH1A1MEN1KMT2APOLBMAPT | |
| SCHEMBL8712014 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760856-B1 | SELECTIVE NR2B ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2016-09-14 | — | — | EP | disclosed |
| WO-2013049119-A1 | SELECTIVE NR2B ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |