Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 2/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SI | P14410 | 2/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21490289 | 0.75 | SLC9A1 (0.75) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL7161071 | 0.73 | SMN1; SMN2 (0.67) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL16042073 | 0.72 | RAB9A (0.51) | GAARAB9ALMNASMN1; SMN2TSHR | |
| SCHEMBL27442555 | 0.72 | KCNMA1 (0.59) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL152998 | 0.71 | NR4A2 (0.50) | GAARAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL29828567 | 0.71 | NR4A2 (0.50) | GAARAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL15766222 | 0.70 | NR4A2 (0.47) | GAASMN1; SMN2TSHRHTTMAPT | |
| SCHEMBL29874714 | 0.70 | NR4A2 (0.49) | GAARAB9ALMNASMN1; SMN2TSHR | |
| SCHEMBL7662781 | 0.70 | NR4A2 (0.49) | GAARAB9ALMNASMN1; SMN2TSHR | |
| SCHEMBL391759 | 0.70 | NR4A2 (0.49) | GAARAB9ALMNASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2578571-A1 | Isoquinoline modulators of ATP-binding cassette transporters | Vertex Pharmaceuticals Incorporated (US) | 2013-04-10 | — | — | EP | disclosed |