Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 2/20 | 0.75 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.51 |
| ▸ | MGAM | O43451 | 2/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SI | P14410 | 2/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14809085 | 0.75 | PTK2 (0.72) | SLC9A1GRM2TDP1ALDH1A1LMNA | |
| SCHEMBL14848341 | 0.75 | MGAM (0.49) | SLC9A1KCNMA1ALDH1A1LMNAHPGD | |
| SCHEMBL14307551 | 0.72 | HPGD (0.70) | SLC9A1GRM2TDP1KCNMA1ALDH1A1 | |
| SCHEMBL2734889 | 0.72 | GRM2 (1.00) | SLC9A1GRM2TDP1KCNMA1ALDH1A1 | |
| SCHEMBL9303187 | 0.70 | KCNMA1 (0.67) | SLC9A1GRM2TDP1KCNMA1ALDH1A1 | |
| SCHEMBL3552907 | 0.70 | KCNMA1 (0.67) | SLC9A1GRM2TDP1KCNMA1ALDH1A1 | |
| SCHEMBL20815428 | 0.69 | KCNMA1 (0.64) | SLC9A1GRM2TDP1KCNMA1ALDH1A1 | |
| SCHEMBL20246151 | 0.69 | SLC9A1 (0.54) | SLC9A1GRM2TDP1KCNMA1ALDH1A1 | |
| SCHEMBL3259919 | 0.68 | SLC9A1 (0.66) | SLC9A1GRM2TDP1KCNMA1HPGD | |
| SCHEMBL189740 | 0.68 | SLC9A1 (0.68) | SLC9A1GRM2TDP1KCNMA1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11851428-B2 | Activator of TREK (TWIK RElated K+channels) channels | ONO PHARMACEUTICAL CO., LTD. (JP) | 2023-12-26 | — | — | US | disclosed |
| US-20210347773-A1 | ACTIVATOR OF TREK (TWIK RELATED K+ CHANNELS) CHANNELS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-11-11 | — | — | US | disclosed |
| US-11046683-B2 | Activator of TREK (TWIK RElated K+ channels) channels | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-06-29 | — | — | US | disclosed |
| US-20190322662-A1 | ACTIVATOR OF TREK (TWIK RELATED K+ CHANNELS) CHANNELS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11851428-B2 | Activator of TREK (TWIK RElated K+channels) channels | KCNJ11, KCNJ1, KCNJ8 | SLC9A1 227/4885GRM2 1453/4885TDP1 1463/4885 |
| US-20190322662-A1 | ACTIVATOR OF TREK (TWIK RELATED K+ CHANNELS) CHANNELS | KCNJ11, KCNJ1, KCNJ8 | SLC9A1 227/4885GRM2 1453/4885TDP1 1463/4885 |
| US-11046683-B2 | Activator of TREK (TWIK RElated K+ channels) channels | KCNJ11, KCNJ1, KCNJ8 | SLC9A1 227/4885GRM2 1453/4885TDP1 1463/4885 |
| US-20210347773-A1 | ACTIVATOR OF TREK (TWIK RELATED K+ CHANNELS) CHANNELS | KCNJ11, KCNJ1, KCNJ8 | SLC9A1 227/4885GRM2 1453/4885TDP1 1463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.