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Tryptophan

Tryptophan

SCHEMBL14856209

CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)OC(=O)[C@@H](N)CO.C[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.42

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.42
▸ MEN1 O00255 2/20 0.42
▸ KDM4E B2RXH2 2/20 0.42
▸ LMNA P02545 2/20 0.42
▸ MAPT P10636 2/20 0.42
▸ TSHR P16473 2/20 0.42
▸ BLM P54132 2/20 0.42
▸ PMP22 Q01453 2/20 0.42
▸ MPO P05164 1/20 0.42
▸ HIF1A Q16665 1/20 0.42
▸ OPRM1 P35372 2/20 0.39
▸ OPRD1 P41143 2/20 0.39
▸ TACR1 P25103 2/20 0.38
▸ HSP90AA1 P07900 1/20 0.38
▸ HSP90AB1 P08238 1/20 0.38
▸ LTA4H P09960 1/20 0.38
▸ PLA2G2A P14555 1/20 0.38
▸ ERAP1 Q9NZ08 4/20 0.37
▸ ERAP2 Q6P179 4/20 0.37
▸ IL1RN P18510 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL14856211 0.93 KMT2A (0.46) KMT2AMEN1KDM4ELMNAMAPT
Tryptophan SCHEMBL6390462 0.84 KMT2A (0.55) KMT2AMEN1KDM4ELMNAMAPT
Dl-Tryptophan SCHEMBL22635843 0.83 KMT2A (0.58) KMT2AMEN1KDM4ELMNAMAPT
Dl-Tryptophan SCHEMBL27659202 0.83 KMT2A (0.47) KMT2AMEN1KDM4ELMNAMAPT
Tyrosine SCHEMBL18614907 0.83 SLC7A5 (0.44) KDM4EHIF1AADORA3ALOX15HTR2A
Tryptophan SCHEMBL1996751 0.82 KMT2A (0.63) KMT2AMEN1KDM4ELMNAMAPT
Dl-Tryptophan SCHEMBL1996746 0.82 KMT2A (0.63) KMT2AMEN1KDM4ELMNAMAPT
Histidine SCHEMBL14691205 0.81 KDM4E (0.55) KMT2AMEN1KDM4ELMNAMAPT
Dl-Tryptophan SCHEMBL1897497 0.81 KMT2A (0.61) KMT2AMEN1KDM4ELMNAMAPT
Tryptophan SCHEMBL1897501 0.81 KMT2A (0.61) KMT2AMEN1KDM4ELMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2580238-A1 DIMERIC VSTM3 FUSION PROTEINS AND RELATED COMPOSITIONS AND METHODS Zymogenetics, Inc. (US) 2013-04-17 — — EP disclosed
WO-2011156356-A1 DIMERIC VSTM3 FUSION PROTEINS AND RELATED COMPOSITIONS AND METHODS ZYMOGENETICS, INC. (US) 2011-12-15 — — WO disclosed
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