Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL14856209 | 0.93 | KMT2A (0.42) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL22635843 | 0.89 | KMT2A (0.58) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL27659202 | 0.88 | KMT2A (0.47) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL1996746 | 0.85 | KMT2A (0.63) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL1996751 | 0.85 | KMT2A (0.63) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL14691207 | 0.85 | KDM4E (0.63) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL1897497 | 0.84 | KMT2A (0.61) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL1897501 | 0.84 | KMT2A (0.61) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL22635845 | 0.84 | KDM4E (0.64) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL28831650 | 0.84 | CTSC (0.41) | KMT2AKDM4EMAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2580238-A1 | DIMERIC VSTM3 FUSION PROTEINS AND RELATED COMPOSITIONS AND METHODS | Zymogenetics, Inc. (US) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011156356-A1 | DIMERIC VSTM3 FUSION PROTEINS AND RELATED COMPOSITIONS AND METHODS | ZYMOGENETICS, INC. (US) | 2011-12-15 | — | — | WO | disclosed |