Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14915112 | 0.70 | RARA (0.35) | ALDH1A1GAAMAPTSMN1; SMN2TDP1 | |
| SCHEMBL14855832 | 0.70 | RARA (0.35) | ALDH1A1GAAMAPTSMN1; SMN2TDP1 | |
| SCHEMBL8097900 | 0.64 | ALDH1A1 (0.38) | ALDH1A1GAAMAPTTDP1TSHR | |
| SCHEMBL14855938 | 0.64 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2TDP1KDM4ETSHR | |
| SCHEMBL14855937 | 0.64 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2TDP1KDM4ETSHR | |
| SCHEMBL13178301 | 0.62 | TDP1 (0.34) | ALDH1A1TDP1KDM4ETSHRHSD17B10 | |
| SCHEMBL13178299 | 0.62 | TDP1 (0.34) | ALDH1A1TDP1KDM4ETSHRHSD17B10 | |
| SCHEMBL13178298 | 0.62 | TDP1 (0.34) | ALDH1A1TDP1KDM4ETSHRHSD17B10 | |
| SCHEMBL1728192 | 0.62 | ALDH1A1 (0.37) | ALDH1A1GAASMN1; SMN2TDP1TSHR | |
| SCHEMBL11618596 | 0.61 | ALDH1A1 (0.50) | ALDH1A1GAAMAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2580210-A2 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | Aragon Pharmaceuticals, Inc. (US) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011156518-A2 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2011-12-15 | — | — | WO | disclosed |