Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL256789 | 0.82 | LMNA (0.50) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL28771457 | 0.80 | ALDH1A1 (0.48) | ACHEKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL29619678 | 0.80 | ALDH1A1 (0.48) | ACHEKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL29619680 | 0.80 | ALDH1A1 (0.48) | ACHEKMT2AMEN1ALDH1A1MAPT | |
| Ammonia Solution, Strong SCHEMBL2441744 | 0.80 | LMNA (0.49) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL104201 | 0.79 | ALDH1A3 (0.54) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL1162019 | 0.79 | ACHE (0.50) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL21868803 | 0.78 | ACHE (0.44) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL12012135 | 0.78 | TDP1 (0.48) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL2738300 | 0.78 | MEN1 (0.39) | KMT2AMEN1ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020230134-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | METABOMED LTD (IL) | 2020-11-19 | — | — | WO | disclosed |
| EP-2895204-A1 | COMPOSITIONS TARGETING BRADYKININ RECEPTOR B1 FOR MEDICAL IMAGING OF CANCER AND OTHER DISORDERS | British Columbia Cancer Agency Branch (CA) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014040192-A1 | COMPOSITIONS TARGETING BRADYKININ RECEPTOR B1 FOR MEDICAL IMAGING OF CANCER AND OTHER DISORDERS | BRITISH COLUMBIA CANCER AGENCY BRANCH (CA) | 2014-03-20 | — | — | WO | disclosed |
| EP-1994004-B9 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |