SCHEMBL14868960

SCHEMBL14868960

Cn1nc2cc(F)c(F)cc2n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.45
HTT P42858 1/20 0.45
CYP11B2 P19099 3/20 0.33
MT-CO1 P00395 2/20 0.33
MT-CO2 P00403 2/20 0.33
CYP11B1 P15538 2/20 0.33
EDNRA P25101 1/20 0.31
OPRM1 P35372 1/20 0.31
HTR2B P41595 1/20 0.31
KCNH2 Q12809 1/20 0.31
ADORA2A P29274 1/20 0.31
ADORA2B P29275 1/20 0.31
KDM4E B2RXH2 1/20 0.31
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
XBP1 P17861 1/20 0.31
MAPK1 P28482 1/20 0.31
RAB9A P51151 1/20 0.31
ATM Q13315 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31600739 0.84 ALOX15 (0.35) ALOX15HTTRAB9A
SCHEMBL31600189 0.84 NPC1 (0.40) ALOX15HTTADORA2AADORA2BKDM4E
Hydrochloric Acid SCHEMBL31600247 0.82 NPC1 (0.39) ALOX15HTTKDM4ELMNAPOLB
SCHEMBL8205559 0.74 KDM4E (0.43) ADORA2AADORA2BKDM4ELMNAPOLB
SCHEMBL19472374 0.74 TOP2A (0.39) ALOX15HTTCYP11B2CYP11B1ADORA2A
SCHEMBL16862907 0.71 TOP2A (0.42) ALOX15HTTCYP11B2CYP11B1LMNA
SCHEMBL31393111 0.69 KDM4E (0.34) KDM4EMAPTRAB9A
SCHEMBL19911639 0.69 SLC9A1 (0.47) ALOX15HTTCYP11B2CYP11B1KDM4E
SCHEMBL6867676 0.69 CHRNB2 (0.45) ALOX15HTTKDM4ELMNAMAPT
SCHEMBL14922469 0.69 NQO2 (0.46) KDM4EPOLBMAPTSMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9184390-B2 Polymers with tunable band gaps for photonic and electronic applications THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2015-11-10 US disclosed
US-20130092912-A1 POLYMERS WITH TUNABLE BAND GAPS FOR PHOTONIC AND ELECTRONIC APPLICATIONS NAVY, SECRETARY OF THE UNITED STATES OF AMERICA 2013-04-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130092912-A1 POLYMERS WITH TUNABLE BAND GAPS FOR PHOTONIC AND ELECTRONIC APPLICATIONS GJB2, PARG, PARN ALOX15 2287/4885HTT 1035/4885CYP11B2 2368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.