Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12905483 | 0.93 | POLB (0.43) | POLBHRH2HRH1MAPTLMNA | |
| SCHEMBL778936 | 0.91 | MMP1 (0.45) | POLBLMNA | |
| SCHEMBL14878440 | 0.91 | ALDH1A1 (0.37) | LMNAGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL14878433 | 0.89 | ALDH1A1 (0.38) | POLBMAPTGAAALDH1A1KMT2A | |
| SCHEMBL14878477 | 0.88 | POLB (0.43) | POLBHRH2HRH1MAPTLMNA | |
| SCHEMBL14878421 | 0.87 | GAA (0.36) | MAPTLMNAGAAALDH1A1KMT2A | |
| SCHEMBL14959560 | 0.87 | ALDH1A1 (0.36) | MAPTLMNAGAAALDH1A1KMT2A | |
| SCHEMBL12905480 | 0.83 | ALDH1A1 (0.37) | LMNAALDH1A1KMT2APSEN1PSEN2 | |
| SCHEMBL14878449 | 0.83 | MMP1 (0.38) | HRH2HRH1KMT2ACYP3A4PSEN1 | |
| SCHEMBL14878434 | 0.83 | MMP1 (0.36) | LMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426415-B2 | Human ADAM-10 inhibitors | SYMPHONY EVOLUTION, INC. (US) | 2013-04-23 | — | — | US | disclosed |