Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.49 |
| ▸ | FPR2 | P25090 | 4/20 | 0.49 |
| ▸ | MMP1 | P03956 | 8/20 | 0.47 |
| ▸ | MMP13 | P45452 | 7/20 | 0.47 |
| ▸ | MMP3 | P08254 | 6/20 | 0.47 |
| ▸ | MMP7 | P09237 | 6/20 | 0.47 |
| ▸ | MMP9 | P14780 | 5/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12905375 | 0.90 | MMP1 (0.45) | SCN9AFPR2MMP1MMP13MMP3 | |
| SCHEMBL778773 | 0.88 | MMP1 (0.63) | MMP1MMP13MMP3MMP7MMP9 | |
| SCHEMBL14878437 | 0.85 | ALDH1A1 (0.44) | MMP1MMP13MMP3MMP7MMP9 | |
| SCHEMBL14878455 | 0.85 | MMP1 (0.52) | MMP1MMP13MMP3MMP7MMP9 | |
| SCHEMBL14878458 | 0.84 | MMP3 (0.49) | SCN9AFPR2MMP1MMP13MMP3 | |
| SCHEMBL14878430 | 0.83 | MMP1 (0.51) | SCN9AFPR2MMP1MMP13MMP3 | |
| SCHEMBL14878456 | 0.82 | MMP1 (0.43) | MMP1MMP13MMP3MMP7MMP9 | |
| SCHEMBL14878432 | 0.82 | SCN9A (0.47) | SCN9AFPR2MMP1MMP13MMP3 | |
| SCHEMBL14878472 | 0.81 | FPR2 (0.39) | SCN9AFPR2MMP1MMP13MMP3 | |
| SCHEMBL14878479 | 0.81 | HTR2C (0.38) | SCN9AFPR2MMP1MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426415-B2 | Human ADAM-10 inhibitors | SYMPHONY EVOLUTION, INC. (US) | 2013-04-23 | — | — | US | disclosed |
| EP-2436676-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |