Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.39 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.39 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14879483 | 0.84 | PTPRC (0.48) | — | |
| SCHEMBL14879594 | 0.83 | RAB9A (0.54) | CRACR2ABRAFCSF1RKDRMAPK14 | |
| SCHEMBL14879545 | 0.81 | POLB (0.43) | CSF1RKITKDR | |
| SCHEMBL14879597 | 0.80 | LRRK2 (0.41) | BRAFCSF1RKITKDR | |
| SCHEMBL14887327 | 0.75 | STIM1 (0.50) | CRACR2ASTIM1ORAI1TRPC1TRPC3 | |
| SCHEMBL14887774 | 0.72 | STIM1 (0.42) | P2RX1CRACR2ASTIM1ORAI1TRPC1 | |
| SCHEMBL14879458 | 0.72 | MEN1 (0.46) | P2RX1L3MBTL1 | |
| SCHEMBL16019815 | 0.71 | STIM1 (0.52) | P2RX1CRACR2ASTIM1ORAI1TRPC1 | |
| SCHEMBL14879607 | 0.71 | NPC1 (0.45) | P2RX1 | |
| SCHEMBL14879598 | 0.68 | TRPA1 (0.47) | P2RX1CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768810-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2014-08-27 | — | — | EP | disclosed |
| WO-2013059666-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |