Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14879607 | 0.88 | NPC1 (0.45) | TDP1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14879598 | 0.88 | TRPA1 (0.47) | MEN1KMT2AHTTRAB9ALMNA | |
| SCHEMBL14879483 | 0.87 | PTPRC (0.48) | MEN1KMT2ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14879487 | 0.82 | TRPV1 (0.47) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL14879421 | 0.72 | P2RX1 (0.40) | L3MBTL1P2RX1 | |
| SCHEMBL14879594 | 0.72 | RAB9A (0.54) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL14879545 | 0.71 | POLB (0.43) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL14879423 | 0.70 | IKBKB (0.35) | — | |
| SCHEMBL16010157 | 0.70 | CRACR2A (0.48) | MEN1KMT2ATDP1ALDH1A1L3MBTL1 | |
| SCHEMBL14879597 | 0.70 | LRRK2 (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768810-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2014-08-27 | — | — | EP | disclosed |
| WO-2013059666-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |