Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | IL2 | P60568 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 3/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14879597 | 0.88 | LRRK2 (0.41) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14879483 | 0.84 | PTPRC (0.48) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL14879594 | 0.81 | RAB9A (0.54) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14879421 | 0.81 | P2RX1 (0.40) | CSF1RKITKDR | |
| SCHEMBL14879598 | 0.78 | TRPA1 (0.47) | CYP1A2IL2LMNAEPAS1HTT | |
| SCHEMBL14879607 | 0.74 | NPC1 (0.45) | MAPTALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL15578007 | 0.72 | MAPT (0.52) | POLBMAPTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL14879553 | 0.71 | GLA (0.38) | POLBMAPTKDM4ETSHRKIT | |
| SCHEMBL16008936 | 0.71 | STIM1 (0.52) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14879458 | 0.71 | MEN1 (0.46) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768810-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2014-08-27 | — | — | EP | disclosed |
| WO-2013059666-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |