SCHEMBL14879798

SCHEMBL14879798

O=C(C=C1CCC1)Nc1cccc(C(=O)N2CCC(c3cccc(CNC(=O)OCc4ccccc4)c3)CC2)c1

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PARP14 Q460N5 3/20 0.44
TGM2 P21980 2/20 0.43
PARP1 P09874 3/20 0.41
F13A1 P00488 1/20 0.40
TGM1 P22735 1/20 0.40
TNKS O95271 2/20 0.39
KDM1A O60341 1/20 0.39
MAOA P21397 1/20 0.39
KDM1B Q8NB78 1/20 0.39
RCOR1 Q9UKL0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14898171 0.83 TGM2 (0.43) TGM2KDM1AMAOAKDM1BRCOR1
SCHEMBL14898129 0.82 TGM2 (0.39) PARP14TGM2PARP1KDM1AMAOA
SCHEMBL14879880 0.81 KMT2A (0.41) TGM2PARP1
SCHEMBL14879876 0.81 BCHE (0.46) PARP14TGM2PARP1F13A1TGM1
SCHEMBL14898127 0.80 KMT2A (0.41) TGM2PARP1
SCHEMBL11903611 0.78 CCR1 (0.48) TGM2F13A1TGM1
SCHEMBL1668574 0.76 ACKR3 (0.43) PARP14TGM2
SCHEMBL14879735 0.76 KMT2A (0.42) PARP14PARP1TNKS
SCHEMBL14879799 0.75 PARP14 (0.42) PARP14TGM2PARP1TNKS
SCHEMBL13976869 0.75 MCHR1 (0.47) TGM2F13A1TGM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11970448-B2 Monomers capable of dimerizing in an aqueous solution, and methods of using same CORNELL UNIVERSITY (US) 2024-04-30 US disclosed
US-20200354319-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME UNIV CORNELL (US) 2020-11-12 US disclosed
US-20140194383-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2014-07-10 US disclosed
US-20140194383-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2014-07-10 US disclosed
EP-2694707-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME Cornell University (US) 2014-02-12 EP disclosed
WO-2013058824-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2013-04-25 WO disclosed
WO-2013058824-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2013-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11970448-B2 Monomers capable of dimerizing in an aqueous solution, and methods of using same CALCOCO2, MDN1, MBNL1 PARP14 1916/4885TGM2 1636/4885PARP1 3642/4885
US-20200354319-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CALCOCO2, MDN1, MBNL1 PARP14 1916/4885TGM2 1636/4885PARP1 3642/4885
US-20140194383-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CALCOCO2, MDN1, MBNL1 PARP14 1916/4885TGM2 1636/4885PARP1 3642/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.