SCHEMBL14879876

SCHEMBL14879876

Nc1cccc(C(=O)N2CCC(c3cccc(CNC(=O)OCc4ccccc4)c3)CC2)c1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.46
PARP14 Q460N5 1/20 0.46
PARP10 Q53GL7 1/20 0.46
MGLL Q99685 2/20 0.45
EGLN1 Q9GZT9 2/20 0.43
TPSAB1 Q15661 1/20 0.43
ACHE P22303 1/20 0.42
BACE1 P56817 1/20 0.42
TGM2 P21980 2/20 0.42
CCR1 P32246 1/20 0.42
F13A1 P00488 1/20 0.42
TGM1 P22735 1/20 0.42
PARP1 P09874 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14879836 0.88 MGLL (0.51) PARP14PARP10MGLLEGLN1TPSAB1
SCHEMBL22652504 0.87 PARP14 (0.44) PARP14PARP10MGLLEGLN1TPSAB1
SCHEMBL11903611 0.85 CCR1 (0.48) TGM2CCR1F13A1TGM1
SCHEMBL14898172 0.85 MGLL (0.45) BCHEPARP14PARP10MGLLTPSAB1
SCHEMBL14898171 0.83 TGM2 (0.43) TGM2
SCHEMBL13976869 0.82 MCHR1 (0.47) BCHETGM2CCR1F13A1TGM1
SCHEMBL14879798 0.81 PARP14 (0.44) PARP14TGM2F13A1TGM1PARP1
SCHEMBL14898129 0.80 TGM2 (0.39) PARP14TGM2PARP1
SCHEMBL1668837 0.80 MGLL (0.56) MGLL
SCHEMBL1668794 0.79 LMNA (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11970448-B2 Monomers capable of dimerizing in an aqueous solution, and methods of using same CORNELL UNIVERSITY (US) 2024-04-30 US disclosed
US-20200354319-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME UNIV CORNELL (US) 2020-11-12 US disclosed
US-20140194383-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2014-07-10 US disclosed
US-20140194383-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2014-07-10 US disclosed
EP-2694707-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME Cornell University (US) 2014-02-12 EP disclosed
WO-2013058824-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2013-04-25 WO disclosed
WO-2013058824-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2013-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11970448-B2 Monomers capable of dimerizing in an aqueous solution, and methods of using same CALCOCO2, MDN1, MBNL1 BCHE 4169/4885PARP14 1916/4885PARP10 1991/4885
US-20200354319-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CALCOCO2, MDN1, MBNL1 BCHE 4169/4885PARP14 1916/4885PARP10 1991/4885
US-20140194383-A1 MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CALCOCO2, MDN1, MBNL1 BCHE 4169/4885PARP14 1916/4885PARP10 1991/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.