Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.80 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.80 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.80 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.80 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.80 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.80 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.80 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.80 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.80 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.80 |
| ▸ | LTA4H | P09960 | 1/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14861225 | 0.89 | HDAC6 (1.00) | HDAC6HDAC1HDAC10HDAC2HDAC8 | |
| SCHEMBL675763 | 0.89 | HDAC6 (1.00) | HDAC6HDAC1HDAC10HDAC2HDAC8 | |
| SCHEMBL1232527 | 0.89 | HDAC6 (1.00) | HDAC6HDAC1HDAC10HDAC2HDAC8 | |
| SCHEMBL13039726 | 0.87 | HDAC6 (0.97) | HDAC6HDAC1HDAC10HDAC2HDAC8 | |
| SCHEMBL28215370 | 0.86 | HDAC6 (0.76) | HDAC6HDAC1HDAC10HDAC2HDAC8 | |
| SCHEMBL1233252 | 0.86 | MAPK1 (0.77) | HDAC6HDAC1HDAC10HDAC2HDAC8 | |
| SCHEMBL13477811 | 0.86 | HDAC6 (0.75) | HDAC6HDAC1HDAC10HDAC2HDAC8 | |
| SCHEMBL15725405 | 0.85 | HDAC6 (0.79) | HDAC6HDAC1HDAC10HDAC2HDAC8 | |
| SCHEMBL2472647 | 0.84 | MAPK1 (0.73) | HDAC6HDAC1HDAC10HDAC2HDAC8 | |
| SCHEMBL14617489 | 0.84 | L3MBTL1 (0.68) | HDAC6HDAC1HDAC10HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130102595-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. | 2013-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102595-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | KRAS, HRAS, KSR2 | HDAC6 20/4885HDAC1 6/4885HDAC10 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.