SCHEMBL14893085

SCHEMBL14893085

O=C(OC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 4/20 0.64
NOTUM Q6P988 1/20 0.55
GAA P10253 1/20 0.46
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46
RXRG P48443 1/20 0.46
P2RX1 P51575 2/20 0.43
HDAC3 O15379 2/20 0.42
HDAC8 Q9BY41 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
CES1 P23141 1/20 0.41
MAPT P10636 1/20 0.41
TACR1 P25103 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HIF1A Q16665 1/20 0.39
RHOC P08134 1/20 0.39
RHOA P61586 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14893086 0.89 P2RX1 (0.54) CES2NOTUMRXRARXRBRXRG
SCHEMBL5274963 0.88 CES2 (0.55) CES2NOTUMGAARXRARXRB
SCHEMBL12429619 0.84 CES2 (0.61) CES2NOTUMGAARXRARXRB
SCHEMBL1999038 0.83 NOTUM (0.77) CES2NOTUMGAAP2RX1HDAC3
SCHEMBL26536749 0.83 CES2 (0.59) CES2NOTUMGAARXRARXRB
SCHEMBL20869052 0.81 CES2 (0.57) CES2NOTUMGAARXRARXRB
SCHEMBL19280563 0.81 CES2 (0.57) CES2NOTUMGAARXRARXRB
SCHEMBL29459924 0.81 CES2 (0.57) CES2NOTUMGAARXRARXRB
SCHEMBL31406174 0.79 CES2 (0.69) CES2P2RX1MAPTNPSR1
SCHEMBL19541391 0.79 NOTUM (0.62) CES2NOTUMGAARXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3635022-B1 METHODS FOR MAKING FUNCTIONALIZED FLUORINATED MONOMERS, FLUORINATED MONOMERS, AND COMPOSITIONS FOR MAKING THE SAME ETNA TEC LTD (US) 2025-05-21 EP disclosed
CN-116354830-A Process for the preparation of functionalized fluorinated monomers, fluorinated monomers and compositions for the preparation thereof 埃特纳科技有限公司 2023-06-30 CN disclosed
CN-110770271-B Method for preparing functionalized fluorinated monomers, fluorinated monomers and compositions for preparing same 埃特纳科技有限公司 2023-04-18 CN disclosed
US-11492318-B2 Methods for making functionalized fluorinated monomers, fluorinated monomers, and compositions for making the same ETNA-TEC, LTD. (US) 2022-11-08 US disclosed
US-20220213016-A1 Methods for Making Functionalized Fluorinated Monomers, Fluorinated Monomers, and Compositions for Making the Same ETNA-TEC, LTD. 2022-07-07 US disclosed
EP-3635022-A1 METHODS FOR MAKING FUNCTIONALIZED FLUORINATED MONOMERS, FLUORINATED MONOMERS, AND COMPOSITIONS FOR MAKING THE SAME Etna-Tec, Ltd (US) 2020-04-15 EP disclosed
US-20180334417-A1 Methods for Making Functionalized Fluorinated Monomers, Fluorinated Monomers, and Compositions for Making the Same ETNA-TEC, LTD. 2018-11-22 US disclosed
US-20180334416-A1 Methods for Making Functionalized Fluorinated Monomers, Fluorinated Monomers, and Compositions for Making the Same ETNA-TEC, LTD. 2018-11-22 US disclosed
WO-2018213850-A1 METHODS FOR MAKING FUNCTIONALIZED FLUORINATED MONOMERS, FLUORINATED MONOMERS, AND COMPOSITIONS FOR MAKING THE SAME ETNA-TEC, LTD (US) 2018-11-22 WO disclosed
US-8795939-B2 Toner, and developer and image forming apparatus using the toner RICOH COMPANY, LTD. (JP) 2014-08-05 US disclosed
US-20130108950-A1 TONER, AND DEVELOPER AND IMAGE FORMING APPARATUS USING THE TONER RICOH COMPANY, LTD. (JP) 2013-05-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180334417-A1 Methods for Making Functionalized Fluorinated Monomers, Fluorinated Monomers, and Compositions for Making the Same ALKBH3, FTO, THEM6 CES2 358/4885NOTUM 16/4885GAA 2927/4885
US-20220213016-A1 Methods for Making Functionalized Fluorinated Monomers, Fluorinated Monomers, and Compositions for Making the Same ALKBH3, FTO, ALK CES2 343/4885NOTUM 21/4885GAA 2983/4885
US-11492318-B2 Methods for making functionalized fluorinated monomers, fluorinated monomers, and compositions for making the same ALKBH3, FTO, ALK CES2 343/4885NOTUM 21/4885GAA 2983/4885
US-20180334416-A1 Methods for Making Functionalized Fluorinated Monomers, Fluorinated Monomers, and Compositions for Making the Same ALKBH3, FTO, ALK CES2 343/4885NOTUM 21/4885GAA 2983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.