Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 4/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209430 | 0.86 | MAPT (0.44) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL21765871 | 0.78 | HRH3 (0.42) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL515186 | 0.76 | MAPT (0.56) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10299392 | 0.76 | IDO1 (0.52) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13534963 | 0.74 | PRSS1 (0.44) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2030465 | 0.74 | IDO1 (0.50) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL514628 | 0.74 | APP (0.47) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL776074 | 0.74 | LMNA (0.58) | NPC1RAB9ALMNAIDO1MAOA | |
| SCHEMBL1145694 | 0.74 | IDO1 (0.50) | NPC1RAB9AMEN1KMT2ASLC6A4 | |
| SCHEMBL14950464 | 0.74 | IDO1 (0.52) | MAPTNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |