Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12260314 | 0.88 | MAPT (0.48) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL7899989 | 0.87 | HTR6 (0.55) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL7899993 | 0.84 | MAPT (0.56) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL20598588 | 0.81 | MAPT (0.60) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL3536101 | 0.79 | ALDH1A1 (0.64) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL7811948 | 0.78 | ALDH1A1 (0.67) | MAPTALDH1A1L3MBTL1GAALMNA | |
| SCHEMBL7809590 | 0.76 | ALDH1A1 (0.58) | MAPTALDH1A1L3MBTL1GAALMNA | |
| SCHEMBL8444725 | 0.76 | ALDH1A1 (0.58) | MAPTALDH1A1L3MBTL1GAALMNA | |
| SCHEMBL3538126 | 0.76 | ALDH1A1 (0.68) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL22094803 | 0.76 | ALDH1A1 (0.68) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594318-A1 | Methods of facilitating cell survival using neurotrophin mimetics | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-2586445-A1 | Methods of facilitating cell survival using neurotrophin mimetics | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2013-05-01 | — | — | EP | disclosed |