Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAC1 | P63000 | 1/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899989 | 0.84 | HTR6 (0.55) | MAPTALDH1A1GAAGLACYP1A2 | |
| SCHEMBL14900317 | 0.84 | MAPT (0.62) | MAPTALDH1A1GAAGLACYP1A2 | |
| SCHEMBL7900012 | 0.77 | MAPT (0.50) | MAPTALDH1A1GAACYP1A2CYP2C19 | |
| SCHEMBL5355772 | 0.75 | MAPT (0.61) | MAPTALDH1A1GAAGLAMEN1 | |
| Hydrochloric Acid SCHEMBL515052 | 0.73 | MAPT (0.59) | MAPTALDH1A1GAAGLAMEN1 | |
| SCHEMBL7520363 | 0.73 | GAA (0.63) | MAPTALDH1A1GAACYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL28432645 | 0.73 | MAPT (0.59) | MAPTALDH1A1GAAGLAMEN1 | |
| SCHEMBL12260314 | 0.73 | MAPT (0.48) | MAPTALDH1A1GAAGLACYP1A2 | |
| SCHEMBL15271381 | 0.71 | SIRT6 (0.81) | MAPTALDH1A1GAAPOLBMEN1 | |
| SCHEMBL6151230 | 0.71 | SIRT6 (0.81) | MAPTALDH1A1GAAPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194399-B1 | E.G., N1-(2-AMINOETHYL)-4-NITRO-N3-(2-PHENOXYETHYL)-1,3-BENZENEDIAMINE AND N-(4-NITRO-N3-(4-(NITROPHENYL)-1-PIPERA-ZINYL)PHENYL)-1,2-ETHANEDIAMINE; BACTERICIDES; DRUG-RESISTANT -LOW RESISTANCE DEVELOPMENT; LOW HALF LIFE; BROAD SPECTRUM | SCRIPTGEN PHARMACEUTICALS, INC. | 2001-02-27 | — | — | US | disclosed |
| WO-2000021539-A1 | ARYLDIAMINE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | ANADYS PHARMACEUTICALS, INC. (US) | 2000-04-20 | — | — | WO | disclosed |