Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14905654 | 0.85 | GABRP (0.36) | MAPTALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL720074 | 0.82 | MAPT (0.45) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL12265096 | 0.81 | MAPT (0.64) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL720432 | 0.78 | L3MBTL1 (0.58) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL717912 | 0.78 | MAPT (0.45) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL718881 | 0.78 | KMT2A (0.52) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL721473 | 0.77 | DGAT1 (0.50) | MAPTALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL27946270 | 0.76 | P2RX7 (0.37) | — | |
| SCHEMBL27834203 | 0.74 | MAPT (0.46) | MAPTALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL14905703 | 0.71 | POLB (0.40) | ALDH1A1KMT2AMEN1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015641-B | Heterocyclic compound | TAKEDA PHARMACEUTICAL | 2014-01-01 | — | — | CN | disclosed |
| US-8436043-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-07 | — | — | US | disclosed |