Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | RAB9A | P51151 | 13/20 | 0.73 |
| ▸ | NPC1 | O15118 | 11/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.73 |
| ▸ | LDHA | P00338 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664159 | 0.85 | LDHA (0.80) | MAPTRAB9ANPC1SMN1; SMN2LDHA | |
| SCHEMBL3923955 | 0.84 | LDHA (1.00) | MAPTRAB9ANPC1SMN1; SMN2LDHA | |
| SCHEMBL15195866 | 0.82 | LDHA (0.76) | MAPTRAB9ANPC1SMN1; SMN2LDHA | |
| SCHEMBL12340976 | 0.82 | MAPT (0.52) | MAPTRAB9ANPC1SMN1; SMN2LDHA | |
| SCHEMBL12344034 | 0.82 | MAPT (0.52) | MAPTRAB9ANPC1SMN1; SMN2LDHA | |
| SCHEMBL23932785 | 0.79 | LDHA (0.74) | MAPTRAB9ANPC1SMN1; SMN2LDHA | |
| SCHEMBL4664151 | 0.78 | LDHA (0.68) | MAPTRAB9ANPC1SMN1; SMN2LDHA | |
| SCHEMBL14079746 | 0.78 | LDHA (0.68) | MAPTRAB9ANPC1SMN1; SMN2LDHA | |
| SCHEMBL30387733 | 0.78 | NPC1 (1.00) | MAPTRAB9ANPC1SMN1; SMN2LDHA | |
| SCHEMBL22894148 | 0.78 | LDHA (0.73) | MAPTRAB9ANPC1SMN1; SMN2LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221841-B2 | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150191490-A1 | MITOTIC KINESIN INHIBTORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2015-07-09 | — | — | US | disclosed |
| EP-1879886-B1 | Inhibitors of mitotic kinesins and their therapeutical use | ARRAY BIOPHARMA INC (US) | 2014-07-09 | — | — | EP | disclosed |
| US-20140018399-A1 | MITOTIC KINESIN INHIBTORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2014-01-16 | — | — | US | disclosed |
| US-8580828-B2 | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2013-11-12 | — | — | US | disclosed |
| US-20130109656-A1 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109656-A1 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | KIF5B, KIF2C, KIFC1 | MAPT 122/4885RAB9A 1590/4885NPC1 512/4885 |
| US-20150191490-A1 | MITOTIC KINESIN INHIBTORS AND METHODS OF USE THEREOF | KIF5B, KIF2C, KIFC1 | MAPT 166/4885RAB9A 2401/4885NPC1 952/4885 |
| US-20140018399-A1 | MITOTIC KINESIN INHIBTORS AND METHODS OF USE THEREOF | KIF5B, KIF2C, KIFC1 | MAPT 166/4885RAB9A 2401/4885NPC1 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.