SCHEMBL1490943

SCHEMBL1490943

C=CC(=O)C=C(c1ccc(O)c(OC)c1)c1ccc(O)c(OC)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
SLC22A6 Q4U2R8 1/20 0.58
SLC22A8 Q8TCC7 1/20 0.58
RAB9A P51151 1/20 0.58
HTT P42858 1/20 0.57
HSD17B2 P37059 1/20 0.50
CYP1A2 P05177 2/20 0.49
HSP90AA1 P07900 1/20 0.49
HSP90AB1 P08238 1/20 0.49
BLM P54132 1/20 0.49
TRPA1 O75762 1/20 0.49
KDM4E B2RXH2 1/20 0.48
POLB P06746 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
ALOX5 P09917 2/20 0.48
CYP2D6 P10635 1/20 0.48
NFKB1 P19838 1/20 0.48
HSD11B1 P28845 1/20 0.48
STAT3 P40763 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16061281 0.92 HTT (0.55) MEN1KMT2ASLC22A6SLC22A8RAB9A
SCHEMBL498487 0.84 MEN1 (0.54) MEN1KMT2ASLC22A6SLC22A8RAB9A
SCHEMBL3691262 0.83 SLC22A6 (0.53) MEN1KMT2ASLC22A6SLC22A8RAB9A
SCHEMBL1490630 0.81 APP (0.46) MEN1KMT2ASLC22A6SLC22A8RAB9A
SCHEMBL3751049 0.81 SLC22A6 (0.66) MEN1KMT2ASLC22A6SLC22A8RAB9A
SCHEMBL10771572 0.79 MEN1 (0.55) MEN1KMT2ASLC22A6SLC22A8RAB9A
Vanillic Acid SCHEMBL26622368 0.78 HTT (0.81) MEN1KMT2ASLC22A6SLC22A8RAB9A
SCHEMBL20897645 0.78 SLC22A6 (0.62) MEN1KMT2ASLC22A6SLC22A8RAB9A
SCHEMBL2524593 0.78 HTT (0.59) MEN1KMT2ASLC22A6SLC22A8RAB9A
Apocynin SCHEMBL31510122 0.77 HTT (0.63) MEN1KMT2ASLC22A6SLC22A8RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2037762-A4 METHOD TO PREPARE PURE CURCUMIN KIM DARRICK S H L (US) 2009-07-08 EP claimed
EP-2037762-A1 METHOD TO PREPARE PURE CURCUMIN Kim, Darrick S.H.L. (US) 2009-03-25 EP claimed
WO-2007143635-A1 METHOD TO PREPARE PURE CURCUMIN KIM DARRICK S (US) 2007-12-13 WO claimed
EP-2477698-A2 COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES Centre National de la Recherche Scientifique (FR) 2012-07-25 EP disclosed
WO-2011033115-A2 COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2011-03-24 WO disclosed
EP-2219600-A1 TOPICAL COSMETIC SKIN LIGHTENING COMPOSITIONS AND METHODS OF USE THEREOF STIEFEL LABORATORIES, INC. (US) 2010-08-25 EP disclosed
WO-2009067095-A1 TOPICAL COSMETIC SKIN LIGHTENING COMPOSITIONS AND METHODS OF USE THEREOF STIEFEL LABORATORIES, INC. (US) 2009-05-28 WO disclosed
EP-2054365-A2 METHODS TO PREPARE PENTA-1,4-DIEN-3-ONES AND SUBSTITUTED CYCLOHEXANONES AND DERIVATIVES WITH ANTITUMORAL AND ANTIPARASITIC PROPERTIES, THE COMPOUNDS AND THEIR USES Uniban - Universidade Bandeirante De São Paulo (BR) 2009-05-06 EP disclosed
EP-1895849-A1 METHODS FOR TREATMENT OF BETA-AMYLOID PROTEIN-INDUCED OCULAR DISEASE Kim, Darrick S.H.L. (US) 2008-03-12 EP disclosed
WO-2008003155-A2 METHODS TO PREPARE PENTA-1,4-DIEN-3-ONES AND SUBSTITUTED CYCLOHEXANONES AND DERIVATIVES WITH ANTITUMORAL AND ANTIPARASITIC PROPERTIES, THE COMPOUNDS AND THEIR USES UNIBAN - UNIVERSIDADE BANDEIRANTE DE SÃO PAULO - ACADEMIA PAULISTA ANCHIETA S/C LTDA (BR) 2008-01-10 WO disclosed
WO-2006138399-A1 METHODS FOR TREATMENT OF BETA-AMYLOID PROTEIN-INDUCED OCULAR DISEASE KIM DARRICK S H L (US) 2006-12-28 WO disclosed
EP-1572614-A2 NEW METHOD FOR THE PREPARATION OF 1,5-BIS(4-HYDROXY-3-METOXY-PHENYL)-PENTA-1,4-DIEN-3-ONE AND DERIVATIVES WITH ANTITUMORAL PROPERTIES Fundacio de Amparo Pesquisa do Estado des Sao Paulo (BR) 2005-09-14 EP disclosed
WO-2004047716-A2 NEW METHOD FOR THE PREPARATION OF 1,5-BIS(4-HYDROXY-3-METOXY-PHENYL)-PENTA-1,4-DIEN-3-ONE AND DERIVATIVES WITH ANTITUMORAL PROPERTIES Fundação De Amparo À Pesquisa Do Estado de São Paulo (BR) 2004-06-10 WO disclosed