Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624926 | 0.85 | NPC1 (0.64) | MAPTHTTALDH1A1ABCG2KMT2A | |
| SCHEMBL12228747 | 0.84 | MAPT (0.82) | MAPTNPSR1HTTALDH1A1POLB | |
| SCHEMBL503802 | 0.82 | POLB (0.70) | MAPTNPSR1HTTALDH1A1POLB | |
| SCHEMBL29581343 | 0.82 | MAPT (0.68) | MAPTNPSR1HTTALDH1A1POLB | |
| SCHEMBL885028 | 0.82 | MAPT (0.68) | MAPTNPSR1HTTALDH1A1POLB | |
| SCHEMBL7074830 | 0.82 | MAPT (0.68) | MAPTNPSR1HTTALDH1A1POLB | |
| SCHEMBL6350154 | 0.81 | ABCG2 (0.67) | MAPTNPSR1HTTALDH1A1POLB | |
| SCHEMBL7511970 | 0.81 | MAPT (0.62) | MAPTNPSR1HTTALDH1A1POLB | |
| SCHEMBL24001 | 0.81 | MAPT (0.66) | MAPTNPSR1HTTALDH1A1POLB | |
| SCHEMBL9185042 | 0.81 | POLB (0.68) | MAPTNPSR1HTTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4456755-A | ANTIBIOTICS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1984-06-26 | — | — | US | claimed |
| US-9981994-B2 | Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2018-05-29 | — | — | US | disclosed |
| EP-2970204-B1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC FOUND FOR RES DEV (US) | 2018-03-28 | — | — | EP | disclosed |
| US-20170121353-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND MEHTODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2017-05-04 | — | — | US | disclosed |
| US-9556207-B2 | Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2017-01-31 | — | — | US | disclosed |
| CN-102532162-B | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| US-20150057247-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2015-02-26 | — | — | US | disclosed |
| US-8921401-B2 | Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2014-12-30 | — | — | US | disclosed |
| US-20140274950-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MEDICAL UNIVERSITY OF SOUTH CAROLINA (US) | 2014-09-18 | — | — | US | disclosed |
| US-8765728-B2 | [1,5]-diazocin derivatives | MELLITECH (FR) | 2014-07-01 | — | — | US | disclosed |
| US-6448295-B1 | TREATING CARDIOVASCULAR DISEASE; ATHEROSCLEROSIS, DYSLIPIDEMA HYPERCHOLESTEROLAEMIA; DECREASING CONCENTRATIONS OF LOW DENSITY LIPOPROTEIN AND RAISING LEVEL OF HIGH DENSITY LIPOPROTEIN | G.D. SEARLE & CO. | 2002-09-10 | — | — | US | disclosed |
| US-5807850-A | Therapeutic agent for osteoporosis and triazepine compound | JAPAN TOBACCO, INC. (JP) | 1998-09-15 | — | — | US | disclosed |
| US-5502025-A | ANTIDOTES FOR HERBICIDES AND PLANT SAFTENING AGENTS | MONSANTO COMPANY (US) | 1996-03-26 | — | — | US | disclosed |
| US-4622394-A | Oxygen analogs of cephalosporins | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1986-11-11 | — | — | US | disclosed |
| US-4456755-A | ANTIBIOTICS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1984-06-26 | — | — | US | disclosed |
| US-4361514-A | Carbon analogs of penicillin | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1982-11-30 | — | — | US | disclosed |
| US-4282149-A | Carbon and oxygen analogs of penicillin | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4154953-A | PURIFICATION, STORAGE STABILITY | SCHERING AKTIENGESELLSCHAFT (DE) | 1979-05-15 | — | — | US | disclosed |
| US-4143046-A | CARBON AND OXYGEN ANALOGS OF PENICILLIN | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1979-03-06 | — | — | US | disclosed |
| US-3984454-A | Crystalline prostanoic acid esters | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121353-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND MEHTODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | PPARD, ACHE, PRNP | MAPT 265/4885NPSR1 2875/4885HTT 52/4885 |
| US-20140274950-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | PPARG, PPARD, PC | MAPT 391/4885NPSR1 3415/4885HTT 152/4885 |
| US-20150057247-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | PPARG, PPARD, PC | MAPT 391/4885NPSR1 3415/4885HTT 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.