Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.37 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.33 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20836182 | 0.83 | NAPRT (0.44) | COMTNAPRTCYP1A2KDM4EALDH1A1 | |
| SCHEMBL30842108 | 0.83 | NAPRT (0.44) | COMTNAPRTCYP1A2KDM4EALDH1A1 | |
| SCHEMBL8031733 | 0.81 | NAPRT (0.42) | COMTNAPRTCYP1A2KDM4EHTT | |
| SCHEMBL1491302 | 0.79 | POLB (0.38) | COMTNAPRTCYP1A2ALDH1A1ALOX15 | |
| SCHEMBL4349196 | 0.78 | TTR (0.46) | COMTCYP1A2KDM4EALDH1A1ALOX15 | |
| SCHEMBL16508198 | 0.78 | CASP6 (0.44) | KDM4EALDH1A1BRAFCA1CA2 | |
| SCHEMBL16508188 | 0.76 | EP300 (0.56) | COMTNAPRTCYP1A2KDM4EHTT | |
| SCHEMBL21801051 | 0.73 | KDM4E (0.53) | KDM4EHTTALDH1A1HSD17B10 | |
| SCHEMBL1491313 | 0.73 | ROCK2 (0.61) | CYP1A2KDM4EHTTALDH1A1HIF1A | |
| SCHEMBL16508210 | 0.73 | HASPIN (0.44) | HASPINNAPRTKDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2296472-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | Amnestix, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009151845-A9 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009151845-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. (US) | 2009-12-17 | — | — | WO | disclosed |