Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918875 | 0.87 | ATM (0.36) | HDAC1HDAC8HDAC6 | |
| SCHEMBL14917800 | 0.86 | HDAC6 (0.41) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL14918554 | 0.83 | HDAC1 (0.53) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL14918374 | 0.83 | PDK1 (0.44) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL14918903 | 0.82 | HDAC1 (0.55) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL14918855 | 0.82 | HDAC1 (0.55) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL14918844 | 0.82 | HDAC1 (0.55) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL14918743 | 0.82 | ALDH1A1 (0.56) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL14918455 | 0.81 | HDAC6 (0.51) | HDAC1HDAC8HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL14918896 | 0.81 | MEN1 (0.41) | HDAC1HDAC8HDAC6SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |