SCHEMBL14918808

SCHEMBL14918808

O=C(CCCc1noc(C(F)(F)F)n1)Nc1ccncn1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 14/20 0.39
HDAC6 Q9UBN7 11/20 0.39
ALDH1A1 P00352 1/20 0.39
GAA P10253 1/20 0.39
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
MAPT P10636 1/20 0.36
HDAC1 Q13547 5/20 0.35
HDAC3 O15379 2/20 0.34
HDAC7 Q8WUI4 2/20 0.34
HDAC2 Q92769 2/20 0.34
HDAC10 Q969S8 2/20 0.34
HDAC11 Q96DB2 2/20 0.34
HDAC8 Q9BY41 2/20 0.34
HDAC9 Q9UKV0 2/20 0.34
HDAC5 Q9UQL6 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
EGFR P00533 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14918419 0.97 HDAC4 (0.38) HDAC4HDAC6ALDH1A1GAALMNA
SCHEMBL14918912 0.96 HDAC4 (0.38) HDAC4HDAC6ALDH1A1GAALMNA
SCHEMBL14918661 0.96 HDAC4 (0.38) HDAC4HDAC6ALDH1A1GAALMNA
SCHEMBL14918624 0.96 HDAC4 (0.38) HDAC4HDAC6ALDH1A1GAALMNA
SCHEMBL14918729 0.93 HDAC4 (0.40) HDAC4HDAC6HDAC1
SCHEMBL14918743 0.86 ALDH1A1 (0.56) HDAC4HDAC6ALDH1A1GAALMNA
SCHEMBL14919093 0.83 HDAC6 (0.44) HDAC4HDAC6ALDH1A1GAALMNA
SCHEMBL14918554 0.83 HDAC1 (0.53) HDAC4HDAC6ALDH1A1GAAHDAC1
SCHEMBL14918875 0.83 ATM (0.36) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL14918855 0.82 HDAC1 (0.55) HDAC4HDAC6ALDH1A1GAALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013066836-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO claimed
WO-2013066836-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed