SCHEMBL14919191

SCHEMBL14919191

CC(C)c1cc(C(=O)O)cc(=O)[nH]1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
LMNA P02545 2/20 0.42
HCAR3 P49019 1/20 0.42
HCAR2 Q8TDS4 1/20 0.42
CYP2C19 P33261 1/20 0.40
TPMT P51580 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
ALOX15 P16050 1/20 0.38
NFKB1 P19838 1/20 0.38
BLM P54132 1/20 0.38
ALKBH5 Q6P6C2 1/20 0.37
EIF4A3 P38919 4/20 0.37
CA12 O43570 2/20 0.35
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA7 P43166 2/20 0.35
CA9 Q16790 2/20 0.35
CA14 Q9ULX7 2/20 0.35
NOTUM Q6P988 1/20 0.35
B3GNT2 Q9NY97 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14967172 0.82 HCAR3 (0.39) ALDH1A1LMNAHCAR3CYP2C19TPMT
SCHEMBL2586738 0.80 CYP1A2 (0.46) ALDH1A1LMNASMN1; SMN2NFKB1CA12
SCHEMBL4429426 0.75 KMT2A (0.40) ALDH1A1LMNACYP2C19KDM4ETP53
SCHEMBL13739553 0.74 NOTUM (0.54) ALDH1A1LMNACYP2C19TPMTSMN1; SMN2
SCHEMBL23684463 0.73 GPR84 (0.43) ALDH1A1LMNACYP2C19TPMTSMN1; SMN2
Citrazinic Acid SCHEMBL8957131 0.71 ALDH1A1 (0.48) ALDH1A1LMNACYP2C19TPMTSMN1; SMN2
SCHEMBL18412738 0.71 DAO (0.39) ALDH1A1LMNAHCAR3HCAR2SMN1; SMN2
SCHEMBL11471145 0.71 DAO (0.39) ALDH1A1LMNACYP2C19SMN1; SMN2CA12
SCHEMBL21282786 0.69 GPR84 (0.41) ALDH1A1BLMCA1KDM4EHPGD
SCHEMBL3525676 0.69 TPMT (0.48) ALDH1A1LMNACYP2C19TPMTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2780013-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF Constellation Pharmaceuticals, Inc. (US) 2014-09-24 EP disclosed
WO-2013075084-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS (US) 2013-05-23 WO disclosed
WO-2013067248-A1 BENZOXAZINES AS MODULATORS OF ION CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-05-10 WO disclosed