SCHEMBL2586738

SCHEMBL2586738

COC(=O)c1cc(C(C)C)[nH]c(=O)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA7 P43166 2/20 0.44
CA9 Q16790 2/20 0.44
CA14 Q9ULX7 2/20 0.44
KDM4E B2RXH2 3/20 0.43
POLB P06746 2/20 0.43
LMNA P02545 2/20 0.43
XDH P47989 2/20 0.43
GAA P10253 1/20 0.43
NFKB1 P19838 1/20 0.43
GFER P55789 1/20 0.43
NFKB2 Q00653 1/20 0.43
RELA Q04206 1/20 0.43
FUT7 Q11130 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
ALDH1A1 P00352 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14966528 0.84 HSD17B10 (0.46) CYP1A2CA12CA1CA2CA7
SCHEMBL14919191 0.80 ALDH1A1 (0.42) CA12CA1CA2CA7CA9
SCHEMBL4433925 0.79 TSHR (0.46) CYP1A2LMNAGAAL3MBTL1ALDH1A1
SCHEMBL2897844 0.77 KDM4E (0.51) CYP1A2CA12CA1CA2CA7
SCHEMBL17112576 0.75 CYP1A2 (0.49) CYP1A2CA12CA1CA2CA7
SCHEMBL17112661 0.72 CYP1A2 (0.46) CYP1A2CA12CA1CA2CA7
SCHEMBL22579440 0.71 CYP1A2 (0.45) CYP1A2CA12CA1CA2CA7
SCHEMBL9412780 0.71 MAPT (0.51) CYP1A2CA12CA1CA2CA7
SCHEMBL8303842 0.71 KIF11 (0.49) CA12CA1CA2CA7CA9
SCHEMBL25787437 0.71 MEN1 (0.50) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2780013-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF Constellation Pharmaceuticals, Inc. (US) 2014-09-24 EP disclosed
EP-2595989-A1 HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS Vertex Pharmaceuticals Incorporated (US) 2013-05-29 EP disclosed
WO-2013075084-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS (US) 2013-05-23 WO disclosed
WO-2013067248-A1 BENZOXAZINES AS MODULATORS OF ION CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-05-10 WO disclosed
WO-2011140425-A1 HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2011-11-10 WO disclosed