Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | COMT | P21964 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919675 | 0.84 | KMT2A (0.56) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL7399750 | 0.76 | ALDH1A1 (0.71) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL14919673 | 0.76 | KMT2A (0.71) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL14919706 | 0.75 | FTO (0.63) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1333403 | 0.75 | COMT (0.63) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1332026 | 0.75 | KMT2A (0.62) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL14919610 | 0.75 | ALDH1A1 (0.78) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL8327919 | 0.74 | KMT2A (0.65) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL14919781 | 0.74 | KMT2A (0.70) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL14919337 | 0.73 | KMT2A (1.00) | KMT2AALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066469-A2 | KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS | SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2013-05-10 | — | — | WO | disclosed |