Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.39 |
| ▸ | HPGD | P15428 | 8/20 | 0.39 |
| ▸ | GAA | P10253 | 7/20 | 0.39 |
| ▸ | CASP1 | P29466 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | PPIB | P23284 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 5/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595165 | 0.89 | KMT2A (0.40) | KDM4EKLK7ALDH1A1HPGDGAA | |
| SCHEMBL2592656 | 0.88 | HSD11B1 (0.39) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL2590155 | 0.85 | KMT2A (0.35) | KDM4EALDH1A1KMT2A | |
| SCHEMBL14919186 | 0.82 | HDAC8 (0.34) | KDM4EALDH1A1GAAHSD17B10KMT2A | |
| SCHEMBL2594530 | 0.77 | KMT2A (0.39) | ALDH1A1GAAKMT2ASMN1; SMN2POLB | |
| SCHEMBL2588272 | 0.77 | GPR119 (0.40) | KMT2A | |
| SCHEMBL2592446 | 0.74 | GPR119 (0.38) | KDM4EKMT2A | |
| SCHEMBL2594720 | 0.72 | ALDH1A1 (0.59) | KDM4EKLK7ALDH1A1HPGDGAA | |
| SCHEMBL2586856 | 0.72 | GPR119 (0.40) | KMT2A | |
| SCHEMBL14972718 | 0.69 | EPHX2 (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013067248-A1 | BENZOXAZINES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-10 | — | — | WO | disclosed |