Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | COMT | P21964 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15116254 | 0.84 | L3MBTL1 (0.61) | NPC1GAALMNAMAPTRECQL | |
| SCHEMBL14919311 | 0.82 | NPC1 (1.00) | NPC1LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL8006512 | 0.82 | L3MBTL1 (0.58) | NPC1GAALMNAMAPTRECQL | |
| SCHEMBL8388796 | 0.82 | L3MBTL1 (0.58) | NPC1GAALMNAMAPTRECQL | |
| SCHEMBL10339234 | 0.78 | ALDH1A1 (0.61) | GAALMNAMAPTRECQLALDH1A1 | |
| SCHEMBL17960031 | 0.76 | COMT (0.60) | GAALMNAMAPTRECQLALDH1A1 | |
| SCHEMBL1333403 | 0.75 | COMT (0.63) | GAALMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL1332026 | 0.75 | KMT2A (0.62) | GAALMNAMAPTRECQLALDH1A1 | |
| SCHEMBL14919706 | 0.75 | FTO (0.63) | GAALMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL14919683 | 0.75 | ALDH1A1 (1.00) | GAALMNAMAPTRECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066469-A2 | KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS | SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2013-05-10 | — | — | WO | disclosed |