Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2959785 | 0.87 | KMT2A (0.62) | MAPTHSD11B1KMT2AMEN1ALDH1A1 | |
| SCHEMBL14919733 | 0.80 | ALDH1A1 (0.73) | MAPTMAPK1HSD11B1KMT2AMEN1 | |
| SCHEMBL2950381 | 0.76 | MEN1 (0.60) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL7340782 | 0.75 | HSD11B1 (0.59) | MAPTHSD11B1KMT2AMEN1ALDH1A1 | |
| SCHEMBL334128 | 0.75 | MGLL (0.67) | MAPTHSD11B1KMT2AMEN1TDP1 | |
| SCHEMBL11508240 | 0.73 | MEN1 (0.65) | MAPK1HSD11B1KMT2AMEN1ALDH1A1 | |
| SCHEMBL1711126 | 0.73 | HSD11B1 (0.70) | MAPTHSD11B1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2953603 | 0.73 | MAPT (0.59) | MAPTHSD11B1KMT2AMEN1ALDH1A1 | |
| SCHEMBL15271381 | 0.71 | SIRT6 (0.81) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL6151230 | 0.71 | SIRT6 (0.81) | MAPTKMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066469-A2 | KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS | SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2013-05-10 | — | — | WO | disclosed |