Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 3/20 | 0.36 |
| ▸ | BECN1 | Q14457 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6302571 | 0.83 | TSHR (0.50) | ACSS2RAB9ANPC1SMN1; SMN2BRD4 | |
| SCHEMBL27851953 | 0.75 | L3MBTL1 (0.35) | ACSS2RAB9ANPC1SMN1; SMN2EGFR | |
| SCHEMBL12158 | 0.74 | USP30 (0.39) | RAB9ANPC1SMN1; SMN2BACE1MEN1 | |
| SCHEMBL30847402 | 0.74 | USP30 (0.39) | RAB9ANPC1SMN1; SMN2BACE1MEN1 | |
| SCHEMBL28680201 | 0.73 | TSHR (0.50) | ACSS2RAB9ANPC1SMN1; SMN2BRD4 | |
| SCHEMBL2724339 | 0.73 | NR1H2 (0.40) | RAB9ANPC1SMN1; SMN2BACE1MEN1 | |
| SCHEMBL482029 | 0.72 | MAPT (0.46) | NPC1SMN1; SMN2MEN1GAAKMT2A | |
| SCHEMBL12567166 | 0.71 | SORT1 (0.43) | LCKRAB9ANPC1RECQLSMN1; SMN2 | |
| SCHEMBL482136 | 0.71 | BACE1 (0.40) | RAB9ANPC1SMN1; SMN2BACE1MEN1 | |
| SCHEMBL32671905 | 0.71 | TSHR (0.55) | ACSS2RAB9ANPC1BRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773641-A1 | BIARYL ETHER SULFONAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013064984-A1 | BIARYL ETHER SULFONAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2013-05-10 | — | — | WO | disclosed |