Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14922983 | 0.79 | DRD1 (0.38) | LMNA | |
| SCHEMBL14596843 | 0.67 | ESR2 (0.41) | GRM2KCNH2GRIN2BPDE2A | |
| SCHEMBL28052513 | 0.66 | SMN1; SMN2 (0.46) | GRM2KCNH2GRIN2BPDE4APDE4B | |
| SCHEMBL10072935 | 0.65 | RAB9A (0.51) | MAOAMAOBLMNACYP1A2HPGD | |
| SCHEMBL7916857 | 0.64 | KIF11 (0.47) | GRIN2B | |
| SCHEMBL9220447 | 0.64 | CYP17A1 (0.46) | GRM2KCNH2GRIN2BLMNA | |
| SCHEMBL20529059 | 0.64 | MAOA (0.44) | GRM2MAOAMAOBPDE4APDE4B | |
| SCHEMBL30244557 | 0.64 | GRIN2B (0.40) | GRM2KCNH2GRIN2BPDE4APDE4B | |
| SCHEMBL18134246 | 0.63 | FASN (0.39) | GRM2PDE4BPDE4DCYP2C9CYP2C19 | |
| SCHEMBL9226568 | 0.63 | PDE3B (0.39) | GRM2GRIN2BPDE3BPDE3ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118067-B1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | SIENA BIOTECH SPA (IT) | 2013-05-08 | — | — | EP | disclosed |