Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4361000 | 1.00 | PTGS2 (0.50) | PTGS2MAPK1ALDH1A1MAPTKDM4E | |
| SCHEMBL4361001 | 1.00 | PTGS2 (0.50) | PTGS2MAPK1ALDH1A1MAPTKDM4E | |
| SCHEMBL11547155 | 0.81 | CYP2D6 (0.44) | PTGS2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL8595189 | 0.79 | PTGS2 (0.37) | PTGS2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL8585835 | 0.79 | PTGS2 (0.53) | PTGS2ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL11594058 | 0.78 | KMT2A (0.57) | ALDH1A1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL6199076 | 0.78 | S100B (0.46) | PTGS2ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL6199068 | 0.78 | S100B (0.46) | PTGS2ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL11462188 | 0.77 | PTGS2 (0.55) | PTGS2ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL8585029 | 0.77 | MEN1 (0.45) | PTGS2MAPTKDM4EKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253231-A1 | DINUCLEAR PLATINUM (II) RED EMITTERS FOR OLED APPLICATIONS | VERSITECH LIMITED (CN) | 2022-12-08 | — | — | WO | disclosed |
| US-11337956-B2 | IRE-1α inhibitors | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2022-05-24 | — | — | US | disclosed |
| US-11299469-B2 | Naphthofuran derivatives, preparation, and methods of use thereof | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2022-04-12 | — | — | US | disclosed |
| US-20210107883-A1 | Naphthofuran Derivatives, Preparation, and Methods of Use Thereof | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2021-04-15 | — | — | US | disclosed |
| EP-3799870-A1 | IRE-1A INHIBITORS | Fosun Orinove Pharmatech, Inc. (CN) | 2021-04-07 | — | — | EP | disclosed |
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |
| US-20190314330-A1 | IRE-1ALPHA INHIBITORS | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2019-10-17 | — | — | US | disclosed |
| US-10357475-B2 | IRE-1α inhibitors | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2019-07-23 | — | — | US | disclosed |
| WO-2018102427-A1 | NAPHTHOFURAN DERIVATIVES, PREPARATION, AND METHODS OF USE THEREOF | BOSTON BIOMEDICAL, INC. (US) | 2018-06-07 | — | — | WO | disclosed |
| US-9867803-B2 | IRE-1α inhibitors | SHANGHAI FOSUN PHARMACEUTICAL INDUSTRIAL DEVELOPMENT CO. LTD. (CN) | 2018-01-16 | — | — | US | disclosed |
| US-8993784-B2 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-20140322713-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-10-30 | — | — | US | disclosed |
| US-20140322713-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-10-30 | — | — | US | disclosed |
| WO-2014135221-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LTD (GB) | 2014-09-12 | — | — | WO | disclosed |
| US-20140255917-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-09-11 | — | — | US | disclosed |
| US-20140255917-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-09-11 | — | — | US | disclosed |
| US-8809551-B1 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-08-19 | — | — | US | disclosed |
| US-8809551-B1 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-08-19 | — | — | US | disclosed |
| US-20130116247-A1 | IRE-1alpha INHIBITORS | MANNKIND CORPORATION (US) | 2013-05-09 | — | — | US | disclosed |
| US-20130116247-A1 | IRE-1alpha INHIBITORS | MANNKIND CORPORATION (US) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140322713-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | POLRMT, FBL, POLM | PTGS2 2667/4885MAPK1 4021/4885ALDH1A1 2698/4885 |
| US-20210107883-A1 | Naphthofuran Derivatives, Preparation, and Methods of Use Thereof | NQO1, CYP2F1, NDUFA1 | PTGS2 1599/4885MAPK1 3827/4885ALDH1A1 61/4885 |
| US-11337956-B2 | IRE-1α inhibitors | XBP1, ERN1, ERN2 | PTGS2 2259/4885MAPK1 470/4885ALDH1A1 1815/4885 |
| US-20190314330-A1 | IRE-1ALPHA INHIBITORS | ERN1, XBP1, ERN2 | PTGS2 2376/4885MAPK1 689/4885ALDH1A1 2024/4885 |
| US-10357475-B2 | IRE-1α inhibitors | XBP1, ERN1, ERN2 | PTGS2 2259/4885MAPK1 470/4885ALDH1A1 1815/4885 |
| US-20130116247-A1 | IRE-1alpha INHIBITORS | ERN1, XBP1, ERN2 | PTGS2 2611/4885MAPK1 689/4885ALDH1A1 2036/4885 |
| US-11299469-B2 | Naphthofuran derivatives, preparation, and methods of use thereof | NQO1, CYP2F1, NDUFA1 | PTGS2 1599/4885MAPK1 3827/4885ALDH1A1 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.