SCHEMBL14928980

SCHEMBL14928980

CC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@@H](OC(C)=O)C1C

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 1/20 0.50
SLC28A2 O43868 1/20 0.50
SLC29A1 Q99808 1/20 0.50
SLC28A3 Q9HAS3 1/20 0.50
TDP1 Q9NUW8 1/20 0.47
P2RY2 P41231 10/20 0.45
P2RY6 Q15077 8/20 0.45
P2RY4 P51582 4/20 0.44
P2RY14 Q15391 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16805354 1.00 SLC28A1 (0.50) SLC28A1SLC28A2SLC29A1SLC28A3TDP1
SCHEMBL16452370 0.91 SLC28A1 (0.52) SLC28A1SLC28A2SLC29A1SLC28A3TDP1
SCHEMBL15497392 0.91 SLC28A1 (0.52) SLC28A1SLC28A2SLC29A1SLC28A3TDP1
SCHEMBL13018205 0.91 SLC28A1 (0.52) SLC28A1SLC28A2SLC29A1SLC28A3TDP1
SCHEMBL18852608 0.91 SLC28A1 (0.52) SLC28A1SLC28A2SLC29A1SLC28A3TDP1
SCHEMBL15276409 0.91 SLC28A1 (0.52) SLC28A1SLC28A2SLC29A1SLC28A3TDP1
SCHEMBL14929229 0.90 P2RY14 (0.46) SLC28A1SLC28A2SLC29A1SLC28A3TDP1
SCHEMBL16805325 0.90 P2RY14 (0.46) SLC28A1SLC28A2SLC29A1SLC28A3TDP1
SCHEMBL25718206 0.89 LMNA (0.53) SLC28A1SLC28A2SLC29A1SLC28A3TDP1
SCHEMBL16808980 0.88 SLC28A1 (0.56) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170175129-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2017-06-22 US disclosed
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Modema Therapeutics, Inc. (US) 2017-05-18 US disclosed
US-20170136132-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2017-05-18 US disclosed
US-20160354493-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX, INC. 2016-12-08 US disclosed
US-20160354491-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160354492-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160348099-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-01 US disclosed
US-20160304552-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. 2016-10-20 US disclosed
US-9428535-B2 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof MODERNA THERAPEUTICS, INC. (US) 2016-08-30 US disclosed
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX, INC. 2015-10-29 US disclosed
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-16 US disclosed
US-20130115272-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160354492-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 SLC28A1 231/4885SLC28A2 204/4885SLC29A1 178/4885
US-20160304552-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 SLC28A1 231/4885SLC28A2 204/4885SLC29A1 178/4885
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 SLC28A1 80/4885SLC28A2 66/4885SLC29A1 41/4885
US-20160348099-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 SLC28A1 231/4885SLC28A2 204/4885SLC29A1 178/4885
US-20170136132-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 SLC28A1 317/4885SLC28A2 259/4885SLC29A1 239/4885
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 SLC28A1 231/4885SLC28A2 204/4885SLC29A1 178/4885
US-20160354491-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 SLC28A1 231/4885SLC28A2 204/4885SLC29A1 178/4885
US-20170175129-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 SLC28A1 317/4885SLC28A2 259/4885SLC29A1 239/4885
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 SLC28A1 317/4885SLC28A2 259/4885SLC29A1 239/4885
US-20160354493-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 SLC28A1 231/4885SLC28A2 204/4885SLC29A1 178/4885
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 SLC28A1 231/4885SLC28A2 204/4885SLC29A1 178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.