Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDA | P32320 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13030852 | 0.76 | POLB (0.48) | CDAALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL26554450 | 0.66 | SLC5A2 (0.31) | — | |
| SCHEMBL26553986 | 0.65 | P2RY6 (0.55) | KMT2AMEN1 | |
| SCHEMBL10026377 | 0.65 | LGALS9 (0.39) | ALDH1A1MAPK1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL15385703 | 0.65 | LGALS9 (0.39) | ALDH1A1MAPK1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL12151652 | 0.65 | LGALS9 (0.39) | ALDH1A1MAPK1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL25824040 | 0.65 | MEN1 (0.40) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL27055213 | 0.65 | MEN1 (0.40) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL25824066 | 0.65 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2BLM | |
| SCHEMBL25824069 | 0.65 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040501-B2 | Compositions and methods for treating cancer | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-05-26 | — | — | US | disclosed |
| US-20140221305-A1 | Compositions and Methods for Treating Cancer | EISAI INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20130116207-A1 | Compositions and Methods for Treating Cancer | EISAI INC. (US) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221305-A1 | Compositions and Methods for Treating Cancer | RNASE1, UNG, HCCS | CDA 537/4885ALDH1A1 196/4885HPGD 276/4885 |
| US-20130116207-A1 | Compositions and Methods for Treating Cancer | RNASE1, UNG, HCCS | CDA 537/4885ALDH1A1 196/4885HPGD 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.