Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14930394 | 0.88 | TSHR (0.47) | MAPK1SMN1; SMN2CYP2C19TSHRALDH1A1 | |
| SCHEMBL3170230 | 0.82 | LMNA (0.64) | MAPK1SMN1; SMN2CYP2C19ALDH1A1KDM4E | |
| SCHEMBL26926832 | 0.81 | MAPK1 (0.49) | MAPK1SMN1; SMN2CYP2C19TSHRALDH1A1 | |
| SCHEMBL14912696 | 0.80 | MITF (0.51) | MAPK1SMN1; SMN2CYP2C19TSHRALDH1A1 | |
| SCHEMBL18730262 | 0.80 | NPC1 (0.47) | MAPK1SMN1; SMN2CYP2C19TSHRALDH1A1 | |
| SCHEMBL15656246 | 0.79 | ALDH1A1 (0.61) | MAPK1SMN1; SMN2CYP2C19TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL21847655 | 0.78 | ALDH1A1 (0.60) | MAPK1SMN1; SMN2CYP2C19TSHRALDH1A1 | |
| SCHEMBL22118978 | 0.78 | TSHR (0.48) | MAPK1SMN1; SMN2CYP2C19TSHRALDH1A1 | |
| SCHEMBL29209544 | 0.77 | TSHR (0.46) | MAPK1SMN1; SMN2CYP2C19TSHRALDH1A1 | |
| SCHEMBL16978039 | 0.77 | TSHR (0.47) | MAPK1SMN1; SMN2CYP2C19TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130116235-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS | GENENTECH, INC. (US) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116235-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS | BTK, PDXK, TYK2 | MAPK1 418/4885SMN1; SMN2 3164/4885CYP2C19 709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.